Contractor for Adme

vor 4 Wochen

Basel, Schweiz Work Selection Vollzeit

**Beschreibung**:
For our international medical partner, F. Hoffmann-La Roche Ltd. in Basel, we are looking for a qualified and motivated **Contractor for ADME - enzymology and DDI** for a temporary contract of 12 months.

**Tasks**:

- Conduct the laboratory-based assays in in vitro enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes
- Analyzing incubation samples via LC-MS/MS and radio-HPLC, including bioanalytical method development and/or validation.
- Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and drug development setting reporting to the respective laboratory staff and supervisors
- Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate
- Some time may be spent in supporting the development of new enzyme phenotyping methodologies and approaches with the help of automation

**Must Haves**:

- You gained good knowledge of metabolic enzyme biochemistry (e.g. CYP450, UGT), hands-on/experimental enzyme kinetics assessment and the respective experimental designs
- Experience in bioanalytical method development/validation for radio-HPLC (e.g. Thermo®) and LC-MS/MS (e.g. Sciex®). This includes troubleshooting and data analysis (e.g.using Analyst® software)
- You have a strong interest in translational approaches leveraging in vitro data and clinical data
- Fluent English

**Nice to have**:

- Previous experience working in the pharmaceutical industry, biotech or CRO
- German skills
- Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies) is an advantage

Wir wertschätzen Vielfalt und begrüssen daher alle Bewerbungen - unabhängig von Geschlecht, sozialer Herkunft, Religion, Alter und Identität. Zur leichteren Lesbarkeit und besseren Verständlichkeit verwenden wir nur eine Gender-Form. Selbstverständlich sind im jeweiligen Kontext alle Genderformen gleichermassen gemeint.

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