Adme Professional Research Associate in Enzymology

vor 1 Woche


Basel, Basel-Stadt, Schweiz Coopers Group AG Vollzeit

ADME Professional Research Associate in Enzymology
For our pharmaceutical client in Basel we are looking for ADME Professional Research Associate in Enzymology.

Start date:
as soon as possible

Duration: 1 year/possible extension

Responsibilities:

  • Conduct the laboratorybased assays in in vitro enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.
  • Analyzing incubation samples via LC-MS/MS and radioHPLC, including bioanalytical method development and/or validation.
  • Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and drug development setting reporting to the respective laboratory staff and supervisors.
  • Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.
  • Some time may be spent in supporting the development of new enzyme phenotyping methodologies and approaches with the help of automation.

Requirements:

  • You have a BSc or MSc degree in chemistry, biochemistry, pharmacokinetics or equivalent discipline.
  • Interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD).
  • You gained good knowledge of metabolic enzyme biochemistry (e.g. CYP450, UGT), handson/experimental enzyme kinetics assessment and the respective experimental designs.
  • Experience in bioanalytical method development/validation for radioHPLC (e.g. Thermo) and LC-MS/MS (e.g. Sciex). This includes troubleshooting and data analysis Analyst software).
  • You have a strong interest in translational approaches leveraging in vitro data and clinical data.
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