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Contractor for Adme

vor 3 Monaten

Basel, Schweiz Flexsis Vollzeit

**INTRODUCTION**:
As a preferred supplier for Roche in Basel, we are looking for a dedicated

**Contractor for ADME - enzymology and DDI (f/m/d)**:
The contract duration is 12 months. The earliest start date is as soon as possible or the latest in May 2024. Remote/Home Office: only occasionally for documentation tasks.

**ASSIGNMENT DESCRIPTION**:

- Conduct the laboratory-based assays in in vitro enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.
- Analyzing incubation samples via LC-MS/MS and radio-HPLC, including bioanalytical method development and/or validation.
- Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and drug development setting reporting to the respective laboratory staff and supervisors.
- Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.
- Some time may be spent in supporting the development of new enzyme phenotyping methodologies and approaches with the help of automation.

**REQUIRED PROFILE**:
Must Haves:

- You gained good knowledge of metabolic enzyme biochemistry (e.g. CYP450, UGT), hands-on/experimental enzyme kinetics assessment and the respective experimental designs.
- Experience in bioanalytical method development/validation for radio-HPLC (e.g. Thermo®) and LC-MS/MS (e.g. Sciex®). This includes troubleshooting and data analysis (e.g.using Analyst® software)
- You have a strong interest in translational approaches leveraging in vitro data and clinical data. Fluent English

Nice to Have:

- Previous experience working in the pharmaceutical industry, biotech or CRO
- German skills
- Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies) is an advantage.

**Application process**

Interested? You can find more information here: