Scientist, Medical Chemistry

vor 4 Monaten

Basel, Schweiz Ridgeline Discovery GmbH Vollzeit

**Ridgeline Discovery is looking for a** Scientist, Medical Chemistry**.**

**Ridgeline Discovery**, a Versant Ventures Discovery Engine, creates and operates Versant-financed innovative biotech companies in partnership with entrepreneurs, industry, and leading academics across Europe. In recent years, Ridgeline has assembled an international team of >50 highly experienced drug discovery and industry professionals and built and operated multiple new successful companies; these companies have raised significant funds through Series B, IPO and an exit through a trade sale.

**RESPONSIBILITIES**

**Design and Synthesis**:

- Contribute to the design of novel, active, and proprietary small molecules, utilizing state-of-the-art medicinal chemistry knowledge.
- Focus on optimizing compounds during the hit-to-lead phase, refining structure-activity relationships (SAR) based on emerging data.
- Proactively propose new strategies and design target molecules to improve compound properties based on biological testing and ADME characterization.

**Execution of Syntheses**:

- Execute the synthesis of small molecules using our CRO network, ensuring timely and reliable delivery of project objectives.
- Maintain a strong background in complex molecule synthesis, utilizing a wide range of techniques related to synthesis, purification, and analysis.

**Collaborative Research**:

- Work closely and collaboratively with our interdisciplinary team of scientists, including biologists, pharmacologists, and DMPK experts, to ensure the advancement of our pipeline objectives.
- Contribute to cross-functional project teams, providing medicinal chemistry expertise and actively participating in strategic discussions.

**Data Analysis and Reporting**:

- Summarize research findings and prepare publications and patents to disseminate results within the scientific community.
- Utilize data analysis tools and databases to inform and refine research strategies.

**Innovation and Development**:

- Stay current with the latest scientific literature and technological advances in medicinal chemistry.

**QUALIFICATIONS**
- Ph.D. in Synthetic Organic Chemistry, Medicinal Chemistry, or a related field.
- Post-doctoral experience is preferred, with 2 to 5 years of experience in the pharmaceutical and/or biotechnology industry.
- Proven experience in medicinal chemistry with a strong emphasis on the hit-to-lead phase and complex molecule synthesis.
- Familiarity with key concepts and optimization strategies in medicinal chemistry, including a clear understanding of ADME properties.
- Basic understanding of disease biology and experience with all stages of pre-clinical research in drug discovery.
- Demonstrated ability to design and synthesize novel small molecules.
- Proficiency in modern synthetic techniques, purification methods, and analytical tools.
- Excellent written and oral communication skills in English, with a proven track record of productive research, as evidenced by publications and/or patents.
- Familiarity with molecular modeling software (e.g., Maestro) and experience with CRO collaboration are considered a plus.

**WHAT WE CURRENTLY OFFER**
- ** People**: We are an international and diverse team with talented and passionate people.
- ** Creativity**: We offer an innovative and creative environment.
- ** Development**: We support the individual development of our employees.
- ** Fun**: From time-to-time we organise cool off-site summer and winter team events.
- ** Offices**: Our well-equipped laboratories and offices are located at the Tech Park, a premier address for early-stage start-ups in Basel.
- ** Commuter Benefits**: We support our employees tailored to their personal needs in commuting to work and offer parking facilities or a commuter contribution.
- ** Flexible Working**: We support flexible working as appropriate.
- ** Christmas Closure**: In addition to the 24 holidays per year, our offices/labs are closed between Christmas and New Year.
- ** Birthday Retreat**: On top of that, your birthday is your personal holiday - our employees enjoy their birthday with a day off.
- ** Food**: We like get-togethers during lunch time. Enjoy tasty, subsidised meals from our FELFEL food fridge.
- ** Coffee**: Meet up with your colleagues and grab free coffee.

**Job-ID**:
RLD-082

**Function**:
Scientist

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