Adme Professional Research Associate in Enzymology
vor 2 Wochen
**ADME Professional Research Associate in Enzymology**
For our pharmaceutical client in Basel we are looking for ADME Professional Research Associate in Enzymology.
Start date: as soon as possible
Duration: 1 year/possible extension
**Responsibilities**:
- Conduct the laboratory-based assays in in vitro enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.
- Analyzing incubation samples via LC-MS/MS and radio-HPLC, including bioanalytical method development and/or validation.
- Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and drug development setting reporting to the respective laboratory staff and supervisors.
- Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.
- Some time may be spent in supporting the development of new enzyme phenotyping methodologies and approaches with the help of automation.
**Requirements**:
- You have a BSc or MSc degree in chemistry, biochemistry, pharmacokinetics or equivalent discipline.
- Interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD).
- You gained good knowledge of metabolic enzyme biochemistry (e.g. CYP450, UGT), hands-on/experimental enzyme kinetics assessment and the respective experimental designs.
- Experience in bioanalytical method development/validation for radio-HPLC (e.g. Thermo®) and LC-MS/MS (e.g. Sciex®). This includes troubleshooting and data analysis (e.g.using Analyst® software).
- You have a strong interest in translational approaches leveraging in vitro data and clinical data.
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