Postdoctoral Researcher in T Cell Engineering and Immuno-oncology
vor 2 Wochen
**Contexte**:
The Lausanne University Hospital (CHUV) is one of five Swiss university hospitals. Through its collaboration with the Faculty of Biology and Medicine of the University of Lausanne and the EPFL, CHUV plays a leading role in the areas of medical care, medical research and training.
The Department of Oncology UNIL-CHUV brings together clinical and cancer research in a strong spirit of innovation. It comprises the services of medical oncology, immuno-oncology including advanced cellular therapies, radiation oncology, hematology including stem cell transplantation and the center for experimental therapies. It also integrates the Lausanne branch of the Ludwig Institute for Cancer Research (LICR), particularly in the field of immunotherapy.
Le Centre hospitalier universitaire vaudois (CHUV) est l'un des 5 hôpitaux universitaires suisses. Grâce à sa collaboration avec la Faculté de biologie et médecine de l'Université de Lausanne et l'EPFL, le CHUV joue un rôle de pointe dans les domaines des soins médicaux, de la recherche médicale et de la formation.
Notre département d’oncologie UNIL-CHUV réunit la clinique et la recherche sur le cancer dans un esprit d'innovation. Il regroupe les services d'oncologie médicale, d’immuno-oncologie, de radio-oncologie, d'hématologie avec l'activité de transplantation de la moelle osseuse du CHUV et le centre de thérapies expérimentales. Il intègre également la branche lausannoise du Ludwig Institute for Cancer Research (LICR) pour la recherche sur le cancer, en particulier dans le domaine de l'immunothérapie.
**Mission**:
You will join an ongoing project that is developing a novel chimeric antigen receptor (CAR) T cell therapy for the treatment of acute myeloid leukemia (AML).
Specifically, you will
- Contribute to the development of innovative strategies implementing a new generation of CAR
- Characterize in vitro the function of these novel CAR-T cells including immunological assays, imaging and transcriptomics, and assess their crosstalk with AML cells
- Validate in vivo in mouse models the anti-leukemic activity of the novel CAR-T cells and address the impact on the tumor microenvironment
- Prepare scientific abstracts and reports for presentations
- Participate actively in the common activities of the laboratory and our research community.
Vous allez rejoindre un projet en cours qui vise à développer des nouvelles thérapies cellulaires innovantes à base de récepteurs antigéniques chimériques (CAR). Spécifiquement nous développons une nouvelle approche thérapeutique contre la leucémie myéloïde aigue.
Concrètement, vous allez effectuer des expériences in vitro et in vivo qui vont
- Contribuer à développer des stratégies innovantes de l’ingénierie de cellules T ciblés contre la leucémie myéloïde aigue avec une nouvelle génération de CAR
- Caractériser in vitro la fonction de cellules CAR-T modifiées contre les cancers et caractériser leur transcriptome dans différents contextes
- Valider in vivo la fonction de cellules T modifiées contre les cancers et le microenvironnement tumorale en utilisant des modèles de souris expérimentaux.
Vous allez aussi préparer des rapports scientifiques pour présentations orales et écrites et participer activement aux activités communes du laboratoire.
**Profil**:
- You have recently obtained a PhD in immune-engineering, immunology, cancer or bioengineering
- You have solid experience and are independently working with animal models (LTK1 certificate or equivalent)
- You are proficient in cell culture and gene engineering technologies
- You are an independent user of multicolor flow cytometry (FACS)
- It is a plus if you have experience with immune synapse imaging or analysis of transcriptomics data
- You have an excellent capacity to organize your work and mange experimental timelines and data analysis
- You read and analyze the scientific literature associated with the project and propose ideas for implementation
- You are a dynamic person with a positive attitude who is proactive and solution oriented, and capable of working in a fast-paced evolving academic environment
- You have good communication skills in English in writing and oral, and French is a plus but not required
- You know how to handle standard informatics tools (Microsoft Office, GraphPad Prism, FlowJo) and know how to adapt to the use of new software tools.
- Vous êtes titulaire d’un PhD en Immunologie ou biologie du cancer
- Vous avez travaillé avec modèles de souris (certificat LTK1 ou équivalent)
- Vous êtes compétents en analyses de cytométrie de flux (FACS), une expérience en imagerie de synapse immunitaire et analyses transcriptomiques sont un atout
- Votre excellente capacité d’organisation et de gestion du temps viennent compléter votre rigueur et votre sens de la précision
- De caractère dynamique, vous êtes fort-e de propositions et proactif-ve dans la mise en place de solutions au sein d’un environnement en perpétuelle évolution, lequel demand
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