Research Associate, Yeast Surface Display

vor 10 Stunden

Basel, Schweiz BIIE Vollzeit

Research Associate
The Botnar Institute of Immune Engineering (BIIE) is a non-profit research institute focusing on developing translational solutions for treatment, prevention and diagnostics of diseases relevant in global child & adolescent health. We are looking for a Research Associate to support the design, development, and optimization of yeast surface display platforms to support our cutting-edge research in immune engineering.
Tasks
**The key responsibilities of the Research Associate**:

- Design and construct yeast surface display libraries using molecular biology techniques.
- Develop and optimize protocols for the display of proteins on the surface of yeast cells.
- Screen and select high-affinity binders from yeast display libraries using flow cytometry and other relevant techniques.
- Prepare libraries for high-throughput sequencing.
- Characterize selected proteins using biochemical and biophysical methods.
- Analyze and interpret experimental data, maintaining detailed records of experiments and outcomes.
- Contribute to the development of new technologies and methodologies to improve high-throughput protein expression workflows.
- Prepare technical reports, summaries, protocols, and quantitative analyses.
- Present findings to team members and contribute to scientific discussions within the group.

**Requirements**:
Core skills and experience expected from the Research Associate:

- Bachelor’s or Master’s degree in Molecular Biology, Biochemistry, Chemical Engineering, or related field.
- Experience with yeast surface display technology and protein engineering.
- Familiarity with molecular biology techniques, such as PCR, cloning, and vector construction.
- Experience with flow cytometry for screening and selection from yeast display libraries.
- Experience in recombinant protein expression, purification, and characterization.
- Ability to communicate effectively with both technical and non-technical stakeholders in English.

In addition, these skills make you even more successful in this role:

- Experience in a life science research environment.
- Experience with Benchling for documenting laboratory results and storing data

About the Botnar Institute of Immune Engineering
The Botnar Institute of Immune Engineering (BIIE) is a newly founded non-profit research organization aiming to become a world leading research institute for the advanced study of immunological systems with a mission to develop translational solutions for the diagnosis, treatment and prevention of disease. The scientific foundation of the BIIE and the broader field of Immune Engineering is based on the intersection of three interdisciplinary subdomains: (i) systems immunology, (ii) synthetic immunology and (iii) computational immunology. The BIIE will serve as a hub for multidisciplinary science, by uniting people with diverse expertise in immunology, biomedicine, bioengineering, systems and synthetic biology, computational biology, artificial intelligence and machine learning. As part of the mission of BIIE to make a lasting impact, it will dedicate significant efforts in training early-stage researchers in this unique multidisciplinary environment, thus enabling them to become future leaders in Immune Engineering.

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