Regulation of Cell Division By Stress Granule
vor 2 Monaten
**Regulation of cell division by stress granule components**:
- Réf
- **ABG-112057**
- Sujet de Thèse- 13/03/2023- Financement public/privé- University of Geneva- Lieu de travail- Geneve - Suisse- Intitulé du sujet- Regulation of cell division by stress granule components- Champs scientifiques- Biologie
- Mots clés- cell division, stress granules, development, cell biology, proteomics, genetics, microscopy**Description du sujet**:
- Cell division is key to life as it allows all organisms to reproduce. The many players and processes involved in cell division must be tightly regulated in time and space to ensure the proper segregation of the genetic material to the daughter cells and the development of multicellular organisms.- We have found that the
- _C. elegans_ protein PQN-59 and its human orthologs, UBAP2 and UBAP2L, are required for a successful cell division. These proteins are components of stress granules, phase-separated organelles that are induced by stress (see for example Cirillo et al., 2020; Abbatemarco et al., 2021). Given that organisms must adapt their regulation of cell division to environmental conditions such as stress, the localization of these proteins to stress granules may suggest that they contribute to link stress granules to cell cycle control.- We are looking for a highly motivated student who will study how UBAP2/2L regulate cell division processes in human cells. In parallel, the student will investigate if and how this role in cell division is linked to their stress granule localization and function, by combining several approaches including microscopy, proteomics, genetics, chemical and molecular biology.**Nature du financement**:
- Financement public/privé**Précisions sur le financement**:
**Présentation établissement et labo d'accueil**:
- University of Geneva-
- For more information on the group and on the publications, please look hereStarting date: upon agreement. Duration: 4 years**Site web**:
Scientist with curiosity, passion for science and strong motivation
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