Scientist, Protein Expression

Vor 7 Tagen

Basel, Schweiz BIIE Vollzeit

Scientist, Protein Expression
The Botnar Institute of Immune Engineering (BIIE) is a non-profit research institute focusing on developing translational solutions for treatment, prevention and diagnostics of diseases relevant in global child & adolescent health. We are looking for a Protein Expression Scientist to lead efforts in soluble protein expression for binder screening, high-throughput protein expression systems, and cell line development for stably expressing cell lines. This role is critical for supporting our binder discovery and protein engineering efforts through the rapid and efficient production of recombinant proteins using bacterial, yeast, insect, or mammalian expression systems.

Tasks

The key responsibilities of the Protein Expression Scientist:

  • Recombinant Protein Expression: Design, develop, and optimize expression strategies for recombinant proteins using bacterial, insect, and mammalian expression systems.
  • Protein Purification: Purify recombinant proteins using chromatography techniques (e.g., affinity, ion exchange, size exclusion), troubleshoot purification processes, and ensure the production of high-quality proteins.
  • High-Throughput Antibody Expression: Lead high-throughput antibody production efforts, including transient and stable transfection, expression screening, and large-scale production of antibodies.
  • Cell Line Development: Establish and maintain cell lines for protein expression, including stable cell line generation, clone selection, and characterization for consistent protein yield.
  • Data Analysis: Analyze protein expression and purification data, optimize protocols for yield and quality, and maintain detailed experimental records.
  • Quality Control: Ensure all protein production and purification processes comply with quality control standards, maintaining rigorous attention to detail and data integrity.
  • Collaboration: Work closely with cross-functional teams to support research development projects.Project Management: Manage multiple projects simultaneously, ensuring timely delivery of high-quality proteins for various research programs.
Requirements

Core skills and experience expected from the Research Associate:

  • PhD in Molecular Biology, Biochemistry, Biotechnology, or a related field. Candidates with a Master's degree and significant industry experience may also be considered.
  • Strong expertise in recombinant protein expression and purification, particularly using bacterial, insect, and mammalian systems.
  • Experience with high-throughput protein or antibody production, including transient and stable expression in mammalian cells.
  • Proficiency in chromatographic purification techniques and protein characterization methods (e.g., SDS-PAGE, Western blot, HPLC, mass spectrometry).
  • Familiarity with cell line development and culture techniques, including experience in stable cell line generation.
  • Strong communication skills, both written and verbal, with the ability to present complex scientific data to diverse audiences.

In addition, these skills make you even more successful in this role:

  • Experience with Benchling for documenting laboratory results and storing data

About the Botnar Institute of Immune Engineering

The Botnar Institute of Immune Engineering (BIIE) is a newly founded non-profit research organization aiming to become a world leading research institute for the advanced study of immunological systems with a mission to develop translational solutions for the diagnosis, treatment and prevention of disease. The scientific foundation of the BIIE and the broader field of Immune Engineering is based on the intersection of three interdisciplinary subdomains: (i) systems immunology, (ii) synthetic immunology and (iii) computational immunology. The BIIE will serve as a hub for multidisciplinary science, by uniting people with diverse expertise in immunology, biomedicine, bioengineering, systems and synthetic biology, computational biology, artificial intelligence and machine learning. As part of the mission of BIIE to make a lasting impact, it will dedicate significant efforts in training early-stage researchers in this unique multidisciplinary environment, thus enabling them to become future leaders in Immune Engineering.

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