Protein Expression Scientist
Vor 6 Tagen
We are seeking a highly skilled Protein Expression Scientist to join our team at the Botnar Institute of Immune Engineering (BIIE). As a key member of our research team, you will be responsible for leading efforts in soluble protein expression, high-throughput protein expression systems, and cell line development for stably expressing cell lines.
Key Responsibilities- Design, develop, and optimize expression strategies for recombinant proteins using bacterial, insect, and mammalian expression systems.
- Purify recombinant proteins using chromatography techniques, troubleshoot purification processes, and ensure the production of high-quality proteins.
- Lead high-throughput antibody production efforts, including transient and stable transfection, expression screening, and large-scale production of antibodies.
- Establish and maintain cell lines for protein expression, including stable cell line generation, clone selection, and characterization for consistent protein yield.
- Analyze protein expression and purification data, optimize protocols for yield and quality, and maintain detailed experimental records.
- Ensure all protein production and purification processes comply with quality control standards, maintaining rigorous attention to detail and data integrity.
- Collaborate with cross-functional teams to support research development projects and manage multiple projects simultaneously.
We are looking for a candidate with a PhD in Molecular Biology, Biochemistry, Biotechnology, or a related field. Strong expertise in recombinant protein expression and purification, particularly using bacterial, insect, and mammalian systems, is essential. Experience with high-throughput protein or antibody production, including transient and stable expression in mammalian cells, is also required. Proficiency in chromatographic purification techniques and protein characterization methods is necessary. Familiarity with cell line development and culture techniques, including experience in stable cell line generation, is also essential. Strong communication skills, both written and verbal, with the ability to present complex scientific data to diverse audiences, are required.
In addition, experience with Benchling for documenting laboratory results and storing data is a plus.
About the Botnar Institute of Immune EngineeringThe Botnar Institute of Immune Engineering (BIIE) is a newly founded non-profit research organization aiming to become a world leading research institute for the advanced study of immunological systems with a mission to develop translational solutions for the diagnosis, treatment, and prevention of disease. The scientific foundation of the BIIE is based on the intersection of three interdisciplinary subdomains: (i) systems immunology, (ii) synthetic immunology, and (iii) computational immunology. The BIIE will serve as a hub for multidisciplinary science, uniting people with diverse expertise in immunology, biomedicine, bioengineering, systems and synthetic biology, computational biology, artificial intelligence, and machine learning. As part of the mission of BIIE to make a lasting impact, it will dedicate significant efforts in training early-stage researchers in this unique multidisciplinary environment, enabling them to become future leaders in Immune Engineering.
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