Scientist 3D CNS Model Specialist
vor 1 Woche
At Roche, we are committed to transforming science into medicines that improve patients' lives. Our Pharmaceutical Research and Early Development organization (pRED) is a hub for innovative research, and we are seeking a talented scientist to join our team.
Role MissionIn close collaboration with the Neurosciences and Rare Disease (NRD) Discovery Translation Area, we are looking for an independent and highly motivated scientist to develop and apply patient-relevant human model systems that recapitulate protein aggregates characteristic of Alzheimer's disease.
Your Impact- Develop a 3D co-culture model of the brain, incorporating neurons and glia.
- Establish imaging-based assays to measure glial function in 3D co-culture models.
- Thoroughly characterize cell lines with disease-relevant mutations.
- Independently design, execute, analyze, interpret, and communicate experiments.
- Demonstrate scientific excellence by publishing and presenting at scientific meetings.
- PhD in Bioengineering, Neuroscience, or other relevant areas.
- Hands-on expertise on stem-cell derived models of human brain cell types.
- Experience working with hydrogel-based 3D culture models.
- Experience developing imaging-based functional assays, including image quantification workflows.
- Knowledge of cellular mechanisms driving disease pathology in Alzheimer's disease.
- Strong critical thinking, communication, organization, and presentation skills.
- Ability to navigate in a matrix environment to effectively influence, advise, or consult experts to jointly move projects forward.
- Driven by scientific curiosity and commitment to patients.
Roche is committed to recognizing talent and aptitude. We prioritize encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions, and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
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