Postdoctoral Researcher in DNA Damage Response and Synthetic Lethality

vor 4 Wochen


Basel, Basel-Stadt, Schweiz Roche Vollzeit

The Role

We are seeking a highly motivated Postdoctoral Fellow to join our cross-functional team in the Department of Cancer Cell Targeted Therapies (CCTT) at Roche. As a Postdoctoral Fellow, you will focus on exploratory research projects on genome stability and DNA repair, with a focus on DNA Damage Response (DDR) and Synthetic Lethality for the treatment of various cancer types.

Key Responsibilities

  • Design and execute experiments using molecular and cell biology assays, including fluorescence microscopy and CRISPR technologies.
  • Perform data analysis and communicate scientific progress through internal meetings and publications.
  • Work independently to design, perform, and interpret experiments, and to embark on new scientific methodologies.

Requirements

  • PhD degree in a relevant field, graduated no more than two years ago.
  • Extensive experience with DNA repair-related assays.
  • Strong background in vector design, genetic engineering, and molecular biology techniques.
  • Strong hands-on experience with a wide range of cellular and molecular biology techniques and cellular assays.

Preferred Qualifications

  • Experience in performing genetic screens.
  • Basic programming skills in Python or R.

About the RPF Programme

The Roche Postdoctoral Fellowship (RPF) Programme aims to build and maintain the Scientific Leadership of the future and to provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers and leading academic research groups from around the world.

Working at Roche

As a Postdoctoral Fellow at Roche, you will be based at the Roche Innovation Center in Basel, Switzerland. The duration of the RPF project is initially set for two years, with the possibility of extension for a third year.



  • Basel, Basel-Stadt, Schweiz Roche Vollzeit

    The OpportunityWe are seeking a highly motivated Postdoctoral Fellow to join our cross-functional team in the Department of Cancer Cell Targeted Therapies (CCTT) at Roche. As a Postdoctoral Fellow, you will focus on exploratory research projects on genome stability and DNA repair, with a strong emphasis on DNA Damage Response (DDR) and Synthetic Lethality...


  • Basel, Basel-Stadt, Schweiz Roche Vollzeit

    The OpportunityWe are seeking a highly motivated Postdoctoral Fellow to join our cross-functional team in the Department of Cancer Cell Targeted Therapies at Roche. As a Postdoctoral Fellow, you will focus on exploratory research projects on genome stability and DNA repair, contributing to our efforts in DNA Damage Response (DDR) and Synthetic Lethality for...


  • Basel, Basel-Stadt, Schweiz Roche Vollzeit

    About the PositionAt Roche, we are committed to developing innovative medicines that improve patients' lives. We are seeking a highly skilled Postdoctoral Researcher in Medicinal Chemistry to join our team in Basel, Switzerland.Your MissionAs a Postdoctoral Researcher in Medicinal Chemistry, you will be responsible for accelerating compound synthesis...


  • Basel, Basel-Stadt, Schweiz Department of Biosystems Science and Engineering Vollzeit

    Job DescriptionWe are seeking a highly motivated and collaborative researcher to join our team at the Department of Biosystems Science and Engineering. The successful candidate will work as part of a multidisciplinary team and be passionate about advancing our efforts in synthetic biology and CRISPR screening.Key ResponsibilitiesConduct in vivo single-cell...


  • Basel, Basel-Stadt, Schweiz Roche Vollzeit

    About the RoleWe are seeking a highly motivated and experienced Postdoctoral Researcher in Medicinal Chemistry to join our team in Basel, Switzerland. As a key member of our Medicinal Chemistry Team, you will be responsible for accelerating compound synthesis through automation technology and digitalization.Your Key ResponsibilitiesDesign and implement...


  • Basel, Basel-Stadt, Schweiz The Biozentrum, University of Basel Vollzeit

    About the ProjectWe are seeking a talented Postdoctoral Researcher to join our team at The Biozentrum, University of Basel, in the development of novel mRNA nanotherapeutics against antibiotic-resistant pulmonary infections.Your RoleAs a member of our research group, you will contribute to the design, synthesis, and characterization of mRNA-based...


  • Basel, Basel-Stadt, Schweiz Department of Biosystems Science and Engineering Vollzeit

    Job OpportunityWe are seeking a highly motivated and collaborative researcher to join our team at the Department of Biosystems Science and Engineering. The successful candidate will work as part of a multidisciplinary team and be passionate about advancing our efforts in in vivo single-cell CRISPR screening.Key ResponsibilitiesConduct in vivo single-cell...


  • Basel, Basel-Stadt, Schweiz Department of Biosystems Science and Engineering Vollzeit

    About the PositionWe are seeking a highly motivated postdoctoral researcher to join our team in the Department of Biosystems Science and Engineering at ETH Zurich.The successful candidate will work in a multidisciplinary team and contribute to the advancement of single-cell CRISPR screening efforts.Key ResponsibilitiesConduct in vivo CRISPR screening...


  • Basel, Basel-Stadt, Schweiz The Biozentrum, University of Basel Vollzeit

    Job OpportunityWe are seeking a highly motivated and experienced researcher to join our team at The Biozentrum, University of Basel, as a Postdoctoral Researcher in Urban CO2 Flux Observations and Modeling.About the ProjectThe successful candidate will be involved in our Horizon project CLMS-Cities, which aims to develop a new urban CO2 emission product for...


  • Basel, Basel-Stadt, Schweiz Bio Engineering Laboratory & Novartis Vollzeit

    Job DescriptionThe Bio Engineering Laboratory & Novartis is seeking a highly motivated Postdoctoral Researcher to join our team in developing innovative in vitro kidney models. As a Postdoctoral Researcher, you will contribute to the development of new cell-culture platforms and tissue models that mimic the kidney microenvironment.Your RoleYou will work...


  • Basel, Basel-Stadt, Schweiz Roche Vollzeit

    The RoleYou will be working in the Synthetic Molecules Technical Development team, collaborating closely with Research and Early Development partners and commercial counterparts. Your focus will be on the technical development of our synthetic molecule pipeline and the manufacturing of drug substances and drug products for clinical studies.As a GMP...


  • Basel, Basel-Stadt, Schweiz The Biozentrum, University of Basel Vollzeit

    About the RoleWe are seeking a highly skilled Postdoctoral Researcher to join our team at The Biozentrum, University of Basel. The successful candidate will be involved in our Horizon project CLMS-Cities, focusing on developing a new urban CO2 emission product for the Copernicus Land Monitoring Service (CLMS).Your ResponsibilitiesContribute to the...


  • Basel, Basel-Stadt, Schweiz The Biozentrum, University of Basel Vollzeit

    Your Position As a Postdoctoral Researcher, you will be part of our Horizon project CLMS-Cities, aiming to develop an urban CO2 emission product for the Copernicus Land Monitoring Service. You will collaborate with a multidisciplinary team across Europe, focusing on a novel bottom-up methodology for estimating urban CO2 emissions and evaluating urban eddy...


  • Basel, Basel-Stadt, Schweiz Universitätspital Basel Vollzeit

    About the OpportunityWe are seeking a highly skilled Postdoctoral Researcher to join our team at Universitätspital Basel. This is an exciting opportunity for a researcher with expertise in advanced statistical modeling to contribute to our cutting-edge research projects.Key ResponsibilitiesSupport the development and implementation of parametric causal...


  • Basel, Basel-Stadt, Schweiz The Biozentrum, University of Basel Vollzeit

    Your PositionSoil plays a critical role in the Earth's surface carbon storage. However, the impact of anthropogenic climate forcing on carbon cycling in soils remains unclear, primarily due to the limited understanding of how microbial metabolism and diversity interact to affect carbon partitioning between microbial biomass and respiration. In central...


  • Basel, Basel-Stadt, Schweiz The Biozentrum, University of Basel Vollzeit

    Your PositionSoil serves as a critical carbon reservoir on Earth's surface. The impact of anthropogenic climate forcing on carbon cycling in soils remains unclear, partly due to the limited understanding of how microbial metabolism and diversity interact to affect carbon partitioning between microbial biomass and respiration (carbon use efficiency or CUE)....


  • Basel, Basel-Stadt, Schweiz Bio Engineering Laboratory & Novartis Vollzeit

    Job DescriptionWe are seeking a highly motivated postdoctoral researcher to join our team at the Bio Engineering Laboratory & Novartis to develop innovative in vitro models of the blood-brain barrier. The successful candidate will work closely with our researchers to design, develop, and validate in vitro models of the human and mouse blood-brain barrier for...


  • Basel, Basel-Stadt, Schweiz Bio Engineering Laboratory & Novartis Vollzeit

    Job OpportunityWe are seeking a highly skilled postdoctoral researcher to join our team at the Bio Engineering Laboratory & Novartis. The successful candidate will develop new in vitro models of the human and mouse blood-brain-barrier and benchmark them for preclinical and clinical investigations.Your RoleThe postdoc will work closely with researchers at...


  • Basel, Basel-Stadt, Schweiz Bio Engineering Laboratory & Novartis Vollzeit

    Job OpportunityThe Bio Engineering Laboratory & Novartis seek a highly motivated Postdoctoral Researcher to develop innovative in vitro kidney models. The successful candidate will design and culture advanced cell platforms to mimic the kidney microenvironment, focusing on the functional characterization of renal tubular units.Key ResponsibilitiesDevelop and...


  • Basel, Basel-Stadt, Schweiz The Biozentrum, University of Basel Vollzeit

    Your Position Soil is a critical storage pool for carbon in Earth's surface. How carbon cycling will change in soils as a result of anthropogenic climate forcing remains unclear, in part because of limited mechanistic understanding of how microbial metabolism and diversity combine to affect carbon portioning between microbial biomass and respiration (known...