Postdoctoral Researcher in Medicinal Chemistry
Vor 7 Tagen
About the Role
We are seeking a highly motivated and experienced Postdoctoral Researcher in Medicinal Chemistry to join our team in Basel, Switzerland. As a key member of our Medicinal Chemistry Team, you will be responsible for accelerating compound synthesis through automation technology and digitalization.
Your Key Responsibilities
- Design and implement state-of-the-art scientific research by conducting laboratory experiments, including multi-step organic synthesis and purification of high-quality target molecules for biological screening.
- Design and run high-throughput experiments on a miniaturized scale using automation equipment, continuously implementing new methodologies and innovative technologies to expand the current capabilities.
- Build up photo-redox high-throughput experimentation to rapidly screen various different chemistries with low material consumption.
- Propose and implement innovative and pragmatic solutions to synthetic and technical problems.
- Closely collaborate with project teams to influence and guide the opportunities of late-stage functionalization, library synthesis, and other digital and/or automation applications.
- Work on cutting-edge innovation at the crossroads of automation, digitalization, medicinal chemistry, and compound synthesis.
About You
We are looking for a graduated PhD student who will be available to join our department between July and September 2024. The candidate should possess a very strong background in high-throughput experimentation to accelerate the synthesis of chemical matter for Medicinal Chemistry. In particular, the candidate should bring:
- Demonstrated ability to set up and lead the high-throughput experimentation (HTE) operations in a renowned academic lab.
- Excellent expertise in automation technology and maintenance of the equipment, especially solid dosing and liquid handling connecting with state-of-the-art analytical and purification methodologies.
- Strong background in synthetic methodology development with a focus on photo-redox chemistry, amine synthesis, and organometallic reactions.
- Passion for small molecule synthesis and hands-on chemistry experimentation in the laboratory.
- Preferentially one year of professional experience in the industry within a strong synthetic environment.
- Solid understanding of machine learning concepts for reaction prediction and associated data set requirements. Experience of collecting reaction datasets for machine learning.
- Excellent communication and presentation skills combined with strong interpersonal abilities to build meaningful relationships across the department and project teams.
About Roche
Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions, and grow in their careers. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering complex questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
-
Postdoctoral Researcher in Medicinal Chemistry
vor 2 Monaten
Basel, Basel-Stadt, Schweiz Roche VollzeitAbout the RoleWe are seeking a highly skilled Postdoctoral Researcher in Medicinal Chemistry to join our team at Roche's Pharmaceutical Research and Early Development organisation (pRED). As a key member of our Medicinal Chemistry Team, you will play a crucial role in accelerating compound synthesis through automation technology and digitalization.Key...
-
Postdoctoral Researcher in Medicinal Chemistry
vor 3 Wochen
Basel, Basel-Stadt, Schweiz Roche VollzeitThe PositionWe are seeking a highly motivated and experienced Postdoctoral Researcher in Medicinal Chemistry to join our team in Roche's Pharmaceutical Research and Early Development organisation (pRED). As a key member of our Medicinal Chemistry Team, you will be responsible for accelerating compound synthesis through automation technology and...
-
Research Fellow in Medicinal Chemistry
vor 2 Monaten
Basel, Basel-Stadt, Schweiz Roche VollzeitAbout the RoleWe are seeking a highly skilled Postdoctoral Researcher in Medicinal Chemistry to join our team at Roche. As a key member of our Pharmaceutical Research and Early Development organisation, you will play a critical role in accelerating compound synthesis through automation technology and digitalization.Key ResponsibilitiesDesign and implement...
-
Research Scientist in Medicinal Chemistry
vor 1 Monat
Basel, Basel-Stadt, Schweiz Ridgeline Discovery GmbH VollzeitJob Title: Research Scientist in Medicinal ChemistryRidgeline Discovery GmbH, a leading biotech company, is seeking a highly skilled Research Scientist in Medicinal Chemistry to join our dynamic team in Basel. As a key member of our interdisciplinary team, you will play a crucial role in advancing our innovative drug discovery programs, with a focus on the...
-
Postdoctoral Researcher in Medicinal Chemistry
vor 1 Monat
Basel, Basel-Stadt, Schweiz Roche VollzeitAbout the RoleWe are seeking a highly skilled PostDoc in Medicinal Chemistry to join our team in Basel, Switzerland. As a key member of our Small Molecule Research group, you will play a crucial role in accelerating compound synthesis through automation technology and digitalization.Key ResponsibilitiesDesign and implement state-of-the-art scientific...
-
PostDoc in Medicinal Chemistry
vor 1 Woche
Basel, Basel-Stadt, Schweiz Roche VollzeitThe RoleWe are seeking a highly skilled PostDoc in Medicinal Chemistry to join our team at Roche. As a key member of our Pharmaceutical Research and Early Development organisation, you will be responsible for accelerating compound synthesis through automation technology and digitalization.Your ResponsibilitiesDesign and implement state-of-the-art scientific...
-
Scientist and Medicinal Chemist
vor 3 Wochen
Basel, Basel-Stadt, Schweiz Ridgeline Discovery GmbH VollzeitJob Title: Scientist and Medicinal ChemistRidgeline Discovery GmbH, a leading biotech company, is seeking a highly skilled Scientist and Medicinal Chemist to join our dynamic team in Basel. As a key member of our medicinal chemistry team, you will play a crucial role in advancing our innovative drug discovery programs, with a focus on the hit-to-lead phase...
-
Postdoctoral Researcher in Ancient Sciences
vor 2 Wochen
Basel, Basel-Stadt, Schweiz The Biozentrum, University of Basel VollzeitPostdoctoral Researcher in Ancient SciencesJoin our team at the University of Basel's Department of Ancient Sciences as a postdoctoral researcher. We are seeking a highly motivated and experienced researcher to support our doctoral program.Key Responsibilities:Support doctoral students in their research projectsConduct independent research in the field of...
-
Postdoctoral Researcher in Ancient Sciences
vor 2 Wochen
Basel, Basel-Stadt, Schweiz The Biozentrum, University of Basel VollzeitPostdoctoral Researcher in Ancient SciencesJoin our research team at the University of Basel and contribute to the advancement of knowledge in the field of Ancient Sciences.We are seeking a highly motivated and qualified postdoctoral researcher to join our team and work on a project related to the history and culture of the ancient...
-
Postdoctoral Research Fellow in DNA Damage Response
vor 3 Wochen
Basel, Basel-Stadt, Schweiz Roche VollzeitThe OpportunityWe are seeking a highly motivated Postdoctoral Fellow to join our team in the Department of Cancer Cell Targeted Therapies at Roche. As a Postdoctoral Fellow, you will have the opportunity to work on exploratory research projects focused on genome stability and DNA repair, with a specific emphasis on DNA Damage Response (DDR) and Synthetic...
-
Basel, Basel-Stadt, Schweiz Bio Engineering Laboratory & Novartis VollzeitJob OpportunityWe are seeking a highly motivated Postdoctoral Researcher to join our team at the Bio Engineering Laboratory & Novartis. The successful candidate will contribute to the development of innovative in vitro models of the blood-brain barrier to investigate the efficacy of biotherapeutics against CNS diseases.About the ProjectThis project aims to...
-
Basel, Basel-Stadt, Schweiz Roche VollzeitThe RoleWe are seeking a highly motivated Postdoctoral Fellow to join our cross-functional team in the Department of Cancer Cell Targeted Therapies (CCTT) at Roche. As a Postdoctoral Fellow, you will focus on exploratory research projects on genome stability and DNA repair, with a focus on DNA Damage Response (DDR) and Synthetic Lethality for the treatment...
-
Basel, Basel-Stadt, Schweiz Bio Engineering Laboratory & Novartis VollzeitJob OpportunityWe are seeking a highly motivated Postdoctoral Researcher to join our team at the Bio Engineering Laboratory & Novartis. The successful candidate will work on developing innovative in vitro models of the blood-brain barrier to investigate the efficacy of biotherapeutics against CNS diseases.About the ProjectThis project aims to leverage in...
-
Basel, Basel-Stadt, Schweiz Roche VollzeitThe OpportunityWe are seeking a highly motivated Postdoctoral Fellow to join our cross-functional team in the Department of Cancer Cell Targeted Therapies (CCTT) at Roche. As a Postdoctoral Fellow, you will focus on exploratory research projects on genome stability and DNA repair, with a strong emphasis on DNA Damage Response (DDR) and Synthetic Lethality...
-
Postdoctoral Researcher in Kidney Tissue Engineering
vor 3 Wochen
Basel, Basel-Stadt, Schweiz Bio Engineering Laboratory & Novartis VollzeitPosition: Postdoctoral Researcher in Bioengineering/BiologyDesign and develop innovative cell-culture systems and tissue constructs that replicate the kidney microenvironment.Utilize stem-cell-derived renal cells to establish a functional renal tubular unit.Assess the performance of the tubular unit to confirm its fidelity to actual kidney tissue.Engage in...
-
Postdoctoral Researcher in Kidney Model Development
vor 3 Wochen
Basel, Basel-Stadt, Schweiz Bio Engineering Laboratory & Novartis VollzeitJob Summary:We are seeking a highly motivated Postdoctoral Researcher to join our team at the Bio Engineering Laboratory & Novartis. The successful candidate will be responsible for developing novel in vitro kidney models to mimic the kidney microenvironment.Key Responsibilities:Design and develop novel cell-culture platforms and tissue models to accurately...
-
Basel, Basel-Stadt, Schweiz The Biozentrum, University of Basel VollzeitYour PositionSoil plays a crucial role in storing carbon in the Earth's surface. However, the impact of anthropogenic climate forcing on carbon cycling in soils remains unclear due to limited understanding of how microbial metabolism and diversity affect carbon partitioning between microbial biomass and respiration.In central Europe, increased drought...
-
Postdoctoral Researcher in Kidney Tissue Engineering
vor 3 Wochen
Basel, Basel-Stadt, Schweiz Bio Engineering Laboratory & Novartis VollzeitPosition: Postdoctoral Researcher in Bioengineering/BiologyDesign and implement innovative cell-culture systems and tissue constructs to replicate the kidney microenvironment.Utilize stem-cell-derived renal cells to develop a functional renal tubular unit.Assess the performance of the tubular unit to ensure it accurately reflects kidney tissue...
-
Postdoctoral Researcher in Kidney Tissue Engineering
vor 3 Wochen
Basel, Basel-Stadt, Schweiz Bio Engineering Laboratory & Novartis VollzeitPosition: Postdoctoral Researcher in Bioengineering/BiologyDesign and develop innovative cell-culture systems and tissue constructs that replicate the kidney microenvironment.Utilize stem-cell-derived renal cells to establish a functional renal tubular unit.Assess the performance of the tubular unit to confirm its fidelity to actual kidney tissue.Engage in...
-
Postdoctoral Researcher in Kidney Model Engineering
vor 3 Wochen
Basel, Basel-Stadt, Schweiz Bio Engineering Laboratory & Novartis VollzeitPosition: Postdoctoral Researcher in Bioengineering/BiologyDesign and implement innovative cell-culture systems and tissue constructs to replicate the kidney microenvironment.Utilize stem-cell-derived renal cells to develop a functional renal tubular unit.Assess the performance of the tubular unit to confirm its fidelity to actual kidney tissue.Engage in...
