PostDoc in Medicinal Chemistry
vor 1 Woche
The Role
We are seeking a highly skilled PostDoc in Medicinal Chemistry to join our team at Roche. As a key member of our Pharmaceutical Research and Early Development organisation, you will be responsible for accelerating compound synthesis through automation technology and digitalization.
Your Responsibilities
- Design and implement state-of-the-art scientific research by conducting laboratory experiments, including multi-step organic synthesis and purification of high-quality target molecules for biological screening.
- Design and run high-throughput experiments on a miniaturized scale using automation equipment, continuously implementing new methodologies and innovative technologies to expand the current capabilities.
- Build up photo-redox high-throughput experimentation to rapidly screen various different chemistries with low material consumption.
- Propose and implement innovative and pragmatic solutions to synthetic and technical problems.
- Closely collaborate with project teams to influence and guide the opportunities of late-stage functionalization, library synthesis, and other digital and/or automation applications.
- Work on cutting-edge innovation at the crossroads of automation, digitalization, medicinal chemistry, and compound synthesis.
Your Profile
We are looking for a graduated PhD student who will be available to join our department between July and September 2024. The candidate should possess a very strong background in high-throughput experimentation to accelerate the synthesis of chemical matter for Medicinal Chemistry. In particular, the candidate should bring:
- Demonstrated ability to set up and lead the high-throughput experimentation (HTE) operations in a renowned academic lab.
- Excellent expertise in automation technology and maintenance of the equipment, especially solid dosing and liquid handling connecting with state-of-the-art analytical and purification methodologies.
- Strong background in synthetic methodology development with a focus on photo-redox chemistry, amine synthesis, and organometallic reactions.
- Passion for small molecule synthesis and hands-on chemistry experimentation in the laboratory.
- Preferentially one year of professional experience in the industry within a strong synthetic environment.
- Solid understanding of machine learning concepts for reaction prediction and associated data set requirements. Experience of collecting reaction datasets for machine learning.
- Excellent communication and presentation skills combined with strong interpersonal abilities to build meaningful relationships across the department and project teams.
Our Commitment
Roche commits to recognising talent and aptitude. We prioritise encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions, and grow in their careers. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering complex questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
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