Computational Chemist

Vor 3 Tagen


Basel, Basel-Stadt, Schweiz FTS Food Technology Services AG Vollzeit

At Zenith Therapeutics, we are redefining drug discovery through a cutting-edge approach to protein degradation. Our team has made significant breakthroughs in identifying key ligases that govern the turnover of hard-to-drug transcription factors, converting these pairs into druggable protein-protein interfaces.

We are committed to advancing highly impactful precision medicines across multiple disease areas with an initial focus on oncology and immune modulation.

As a recognized expert in computational chemistry, you will lead our cheminformatics efforts across multiple programs, from library design to advanced optimization. Your expertise will drive our computational approaches for identifying and optimizing molecular glues.

Key Responsibilities

  1. Develop and implement the computational chemistry strategy in collaboration with internal stakeholders.
  2. Design and implement rational approaches for library design, modeling of protein-protein interactions, and compound design.
  3. Analyze complex biochemical and cellular datasets to drive drug discovery decisions.
  4. Support drug discovery programs from initial hit identification to candidate selection.

Required Skills and Qualifications

  • Ph.D. in a relevant field with a strong background in computational chemistry.
  • 5+ years of experience in the pharmaceutical or biotech industry focusing on small molecules.
  • Deep understanding of drug discovery processes, medicinal chemistry, ADMET principles, and multiparameter compound optimization.
  • Proven track record of impacting drug discovery projects in a biotech or pharmaceutical setting through creative computational chemistry approaches.
  • Hands-on expertise in structure-based drug design, cheminformatics, and data analytics/visualization.


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