Computational Chemistry Expert

Vor 5 Tagen


Basel, Basel-Stadt, Schweiz TN Switzerland Vollzeit

Zenith Therapeutics is a pioneering force in drug discovery, redefining the approach to protein degradation through innovative computational methods. Our team has identified key ligases that govern the turnover of hard-to-drug transcription factors, converting these pairs into druggable protein-protein interfaces. With an initial focus on oncology and immune modulation, we are committed to advancing impactful precision medicines across multiple disease areas.

Headquartered in Switzerland, Zenith was created by Ridgeline Discovery, a Versant Ventures Discovery Engine, and is backed by leading investors in the biotech sector. We are seeking an experienced Computational Chemist to join our growing drug discovery team, driving cheminformatics and structure-based efforts across multiple programs – from library design to advanced optimization.

Key Responsibilities:

  • Develop and implement the computational chemistry strategy in collaboration with internal stakeholders.
  • Design and implement rational approaches for library creation, modeling of protein-protein interactions, and compound design.
  • Analyze complex datasets to drive drug discovery decisions.
  • Support drug discovery programs from hit identification to candidate selection.

Qualifications and Skills:

  • Ph.D. in a relevant field and a strong background in computational chemistry.
  • 5+ years of experience in the pharmaceutical or biotech industry focusing on small molecules.
  • Deep understanding of drug discovery processes, medicinal chemistry, ADMET principles, and multiparameter compound optimization.
  • Proven track record of impacting drug discovery projects in a biotech or pharmaceutical setting through creative computational chemistry approaches.
  • Hands-on expertise in structure-based drug design approaches, tools, as well as cheminformatics and data analytics/visualization.
  • Strong communication skills with the ability to build productive relationships and collaborations both internally and externally.


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