Senior/Principal Scientist, Computational Chemistry
vor 3 Wochen
Zenith Therapeutics is redefining drug discovery through a new approach to protein degradation. Our team has identified key ligases that govern the turnover of hard-to-drug transcription factors and convert these pairs into druggable protein-protein interfaces. With an initial focus on oncology and immune modulation, we are committed to advancing highly impactful precision medicines across multiple disease areas.
Headquartered in Basel, Switzerland, Zenith was created by Ridgeline Discovery, a Versant Ventures Discovery Engine, and is backed by leading investors in the biotech sector.
We are looking for an experienced Computational Chemist to join our growing drug discovery team. In this key role, you will lead our computational approaches for identifying and optimizing molecular glues. As a recognized expert in this field, you will drive cheminformatics and structure-based efforts across multiple programs – from library design to advanced optimization.
RESPONSIBILITIES
- Develop and implement the computational chemistry strategy in collaboration with internal stakeholders.
- Develop and implement rational approaches for library design, modeling of protein-protein interactions, and compound design.
- Analyze complex datasets (biochemical and cellular SAR, ADME, PK, and structural data) to drive drug discovery decisions.
- Support drug discovery programs from initial hit identification to candidate selection.
QUALIFICATIONS
- Ph.D. in a relevant field and a strong background in computational chemistry.
- 5+ years of experience in the pharmaceutical or biotech industry focusing on small molecules.
- Deep understanding of drug discovery processes, medicinal chemistry, ADMET principles, and multiparameter compound optimization.
- Proven track record of impacting drug discovery projects in a biotech or pharmaceutical setting through creative computational chemistry approaches.
- Hands-on expertise in structure-based drug design approaches, tools, cheminformatics, and data analytics/visualization.
- Strong communication skills with the ability to build productive relationships and collaborations both internally and externally.
- Thrive in a dynamic, fast-paced environment where you take full ownership of your contributions and development.
WHAT WE CURRENTLY OFFER
- People: We are an international and diverse team with talented and passionate people.
- Creativity: We offer an innovative and creative environment.
- Development: We support the individual development of our employees.
- Fun: We organize off-site summer and winter team events.
- Offices: Our well-equipped laboratories and offices are located at the Tech Park, a premier address for early-stage start-ups in Basel.
- Commuter Benefits: We support our employees tailored to their personal needs in commuting to work.
- Flexible Working: We support flexible working as appropriate.
- Christmas Closure: Our offices/labs are closed between Christmas and New Year.
- Birthday Retreat: Enjoy your birthday with a day off.
- Food: Enjoy tasty, subsidised meals from our FELFEL food fridge.
- Coffee: Meet up with your colleagues and grab free coffee.
To apply, please submit your completed application form along with your CV, cover letter, and reference letters (Arbeitszeugnisse).
#J-18808-Ljbffr-
Advanced Computational Chemistry Position
Vor 4 Tagen
Basel, Basel-Stadt, Schweiz The Computational Chemistry List VollzeitJoin Our Team in Basel, SwitzerlandWe are seeking a highly qualified postdoctoral researcher to join our group at the Department of Chemistry, University of Basel, Switzerland. As a member of our team, you will contribute to cutting-edge research in theoretical and computational chemistry, working closely with our team to advance our understanding of complex...
-
Principal Scientist in Computational Approaches
Vor 5 Tagen
Basel, Basel-Stadt, Schweiz TN Switzerland VollzeitAt Zenith Therapeutics, we are committed to advancing impactful precision medicines across multiple disease areas. We are seeking a talented Principal Scientist to join our growing drug discovery team, contributing to the development of novel therapeutic approaches through cutting-edge computational methods.As a key member of our team, you will drive...
-
Senior/Principal Scientist& Computational Chemistry
vor 3 Wochen
Basel, Schweiz TN Switzerland VollzeitSocial network you want to login/join with:Senior/Principal Scientist & Computational Chemistry / CADD & Cheminformatics, BaselJob Description:Zenith Therapeutics is redefining drug discovery through a new approach to protein degradation. Our team has identified key ligases that govern the turnover of hard-to-drug transcription factors and convert these...
-
Basel, Schweiz TN Switzerland VollzeitSocial network you want to login/join with:Senior/Principal Scientist & Computational Chemistry / CADD & Cheminformatics, Basel-StadtClient:Location:Job Category:Other-Job Reference:352392abbfeaJob Views:4Posted:06.03.2025Expiry Date:20.04.2025Job Description:Zenith Therapeutics is redefining drug discovery through a new approach to protein degradation. Our...
-
Postdoctoral Researcher in Chemistry
Vor 4 Tagen
Basel, Basel-Stadt, Schweiz The Computational Chemistry List VollzeitWelcome to our job listing for a postdoctoral position in theoretical and computational chemistry! We are excited to offer this opportunity for a talented researcher to join our team at the Department of Chemistry, University of Basel, Switzerland.About Our Research:Our research group focuses on developing and applying advanced computational tools for...
-
Basel, Basel-Stadt, Schweiz Ridgeline Discovery GmbH VollzeitZenith Therapeutics is redefining drug discovery through a new approach to protein degradation. Our team has identified key ligases that govern the turnover of hard-to-drug transcription factors and convert these pairs into druggable protein-protein interfaces. With an initial focus on oncology and immune modulation, we are committed to advancing highly...
-
Chemistry Department Job Opening
Vor 4 Tagen
Basel, Basel-Stadt, Schweiz The Computational Chemistry List VollzeitResearch Opportunities in Basel, SwitzerlandWe invite applications for a postdoctoral position in the Department of Chemistry at the University of Basel, Switzerland. Our research group focuses on theoretical and computational chemistry, with a particular emphasis on machine learning and molecular simulations.Your Role:You will work closely with our team to...
-
Senior/Principal Scientist, Computational Chemistry
vor 3 Wochen
Basel, Schweiz Matterhorn Biosciences AG VollzeitZenith Therapeutics is redefining drug discovery through a new approach to protein degradation. Our team has identified key ligases that govern the turnover of hard-to-drug transcription factors and convert these pairs into druggable protein-protein interfaces. With an initial focus on oncology and immune modulation, we are committed to advancing highly...
-
Basel, Schweiz The Computational Chemistry List VollzeitCCL 25.02.24 Postdoctoral Position, Chemistry Department, Uni Basel, Switzerland (Group Meuwly)Applications are invited for postdoctoral positions in theoretical and computational chemistry in the group of Markus Meuwly, Department of Chemistry, University of Basel, Switzerland. The initial appointment is for one year, with the possibility to renew for a...
-
Theoretical Chemist Wanted
Vor 4 Tagen
Basel, Basel-Stadt, Schweiz The Computational Chemistry List VollzeitCCL Postdoctoral Position, Chemistry Department, Uni Basel, Switzerland (Group Meuwly)We are seeking a highly skilled postdoctoral researcher to join our group at the Department of Chemistry, University of Basel, Switzerland. The successful candidate will have a strong background in computational and theoretical chemistry.The main theme of our research is...
-
Senior Scientist in Drug Discovery
Vor 5 Tagen
Basel, Basel-Stadt, Schweiz TN Switzerland VollzeitWe are seeking a highly skilled Senior Scientist to join our drug discovery team at Zenith Therapeutics. As a key member of our team, you will contribute to the development of novel therapeutic approaches, leveraging cutting-edge computational methods to drive innovation in protein degradation.Our company is headquartered in Switzerland and is backed by...
-
Computational Chemistry Expert
Vor 5 Tagen
Basel, Basel-Stadt, Schweiz TN Switzerland VollzeitZenith Therapeutics is a pioneering force in drug discovery, redefining the approach to protein degradation through innovative computational methods. Our team has identified key ligases that govern the turnover of hard-to-drug transcription factors, converting these pairs into druggable protein-protein interfaces. With an initial focus on oncology and immune...
-
Basel, Basel-Stadt, Schweiz Karlstad University VollzeitAt Karlstad University, we are seeking a highly motivated and skilled Research Scientist to join our team in the Department of Biomedicine and Department of Chemistry. As a Research Scientist, you will play a key role in advancing our understanding of cancer biology and developing novel therapeutic strategies.Job DescriptionWe are looking for a talented...
-
Basel, Basel-Stadt, Schweiz Roche VollzeitRoche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people's varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche,...
-
Basel, Basel-Stadt, Schweiz F. Hoffmann-La Roche AG VollzeitWe're looking for a highly experienced Library Enhancement, Data and Computational Chemistry Expert to join our team in Basel, Switzerland.In this role, you will leverage your expertise in cheminformatics, data science, and computational chemistry to develop and implement novel solutions to optimize small molecule screening activities and streamline data...
-
Scientist / Senior Scientist
vor 2 Wochen
Basel, Basel-Stadt, Schweiz Gi Group SA VollzeitIn Roche's Pharmaceutical Research and Early Development organization (pRED), transformative medicines are made for patients to tackle some of the world's toughest unmet healthcare needs. pRED is recruiting a Scientist/Senior Scientist to the Systems Biology group, part of the Cardiometabolic, Immunology, Infectious Diseases, and Ophthalmology (CMI2O)...
-
Scientist / Senior Scientist
vor 2 Wochen
Basel, Basel-Stadt, Schweiz Gi Group SA VollzeitIn Roche's Pharmaceutical Research and Early Development organization (pRED), transformative medicines are made for patients to tackle some of the world's toughest unmet healthcare needs. pRED is recruiting a Scientist/Senior Scientist to the Systems Biology group, part of the Cardiometabolic, Immunology, Infectious Diseases, and Ophthalmology (CMI2O)...
-
Principal Scientist
vor 6 Stunden
Basel, Basel-Stadt, Schweiz myScience VollzeitPrincipal Scientist - Crop Protection Research Chemistry (m/f/d)SyngentaPublished 10 March 2025Workplace Basel, North West Switzerland, SwitzerlandCategory Agronomy / Food ScienceChemistryPosition Regular Employment / Collaborator1. __vacancyopjusttionswidget.opt- Brand__ Syngenta Crop Protection2. Location: Stein3. Function Research ChemistryJob...
-
Principal Scientist
vor 2 Wochen
Basel, Schweiz Batterman Consulting Basel AG Vollzeit**Our Client** **Principal Scientist****: **Your responsibilities** - Provide key biology expertise and leadership for defined programs throughout discovery and development stages - Identify and design experimental work plans to address program needs at various stages - Participation in scientific review and assessment of potential new and/or existing...
-
Computational Chemist
Vor 4 Tagen
Basel, Basel-Stadt, Schweiz FTS Food Technology Services AG VollzeitAt Zenith Therapeutics, we are redefining drug discovery through a cutting-edge approach to protein degradation. Our team has made significant breakthroughs in identifying key ligases that govern the turnover of hard-to-drug transcription factors, converting these pairs into druggable protein-protein interfaces.We are committed to advancing highly impactful...