Biotechnology Engineer for In Vitro Culture Systems

Vor 6 Tagen

Basel, Basel-Stadt, Schweiz F. Hoffmann-La Roche AG Vollzeit
Role Overview

The Roche Institute of Human Biology is seeking a highly skilled Automation Scientist to join our dynamic research team. As an integral member, you will contribute to the development, optimization, and implementation of advanced in vitro culture protocols on a plate-based automation platform.

You will collaborate with multidisciplinary teams to design, evaluate, and deploy groundbreaking in vitro culture methodologies within an automated laboratory environment. Your contributions will directly support the establishment of robust Standard Operating Procedures (SOPs) and enhance the scalability and reproducibility of human in vitro model systems.

Main Responsibilities:

  • Collaborate with research teams to develop, validate, and implement new automation workflows for human in vitro model systems.
  • Design and program various liquid handling systems for automated organoid culture, including troubleshooting and optimization processes.
  • Oversee and manage the seamless operation of multiple sophisticated, scheduled workflows for automated culture systems.
  • Ensure compliance with quality control standards and best practices for automated culture systems, while developing, documenting, and validating SOPs to support process standardization in a manufacturing environment.
  • Stay informed on scientific advancements by reviewing literature on innovative automated in vitro culture techniques, and evaluate external products and equipment to enhance automation capabilities.
  • Train, mentor, and supervise junior team members, including Research Associates and Interns.
About You

You are a scientist or engineer with a MSc or a PhD and extensive experience in automation for biological systems, preferably with liquid handling platforms and/or integrated robotic systems.

  • Automation & Programming – Proficient in Python, C++, and workflow scripting for liquid handling systems.
  • Robotic Systems & Liquid Handling – Hands-on experience with robotic pipetting, liquid handling platforms, and scheduling software.
  • Workflow Design & Optimization – Ability to design, implement, and improve automated workflows with structured troubleshooting.
  • Interdisciplinary Collaboration – Strong team player in multidisciplinary environments with excellent communication skills.
  • Imaging & Machine Learning (Advantageous) – Experience with high-content imaging, image analysis, and ML algorithms.
  • 3D Cell Cultures & Specialized Liquids (Advantageous) – Familiarity with organoids, spheroids, tumoroids, and handling viscous liquids (e.g., Matrigel).

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