Research Assistant Protein Production
vor 3 Wochen
IOB is a new research institute combining basic and clinical research. Its mission is to drive innovations in understanding vision and its related diseases and to develop new therapies for vision loss. It is a place where your expertise will be valued, your abilities challenged, and your knowledge expanded.
**Your position**
- Develop protein expression in (transient) mammalian and microbial systems to produce antigens for binder selection campaigns
- Establish small scale protein production for functional binder screening and characterization
- Design and cloning of expression constructs
- Interact with researchers to support therapeutic projects and development of the protein engineering platform
- Assist in binder discovery campaigns and characterization of novel protein binders
- Assist with lab management duties
**Your profile**
- Degree (apprenticeship, BSc/MSc or PhD) in Biology, Biochemistry or similar discipline
- Practical experience with recombinant protein expression in different hosts (i.e. bacterial and mammalian)
- Hands-on knowledge with state-of-the-art protein purification technologies like affinity, size exclusion or ion exchange chromatography
- Knowledge of molecular cloning methods
- Basic protein characterization methods (e.g. SDS-PAGE, ELISA, western blots)
**Additional skills (advantageous but not required)**:
- Protein-protein interaction analysis, e.g. by ELISA, surface plasmon resonance, biolayer interferometry
- In-vitro display methods, e.g. phage, yeast or ribosome display
- Structural biology or modeling of protein structures
This position is hands-on and demands both an independent working style and an ability to interact comfortably with users of the protein engineering platform. Openness to innovative non-traditional solutions is important.
**We offer you**
- Highly competitive conditions in a dynamic and international research community in Basel;
- IOB is an equal-opportunity employer with family-friendly work policies.
**Application / Contact**
IOB - Institute of Molecular and Clinical Ophthalmology Basel
Sandro Crameri
Head of Human Resources
Phone number: +41 79 511 26 54
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