Postdoctoral Researcher

vor 2 Monaten


Basel, Schweiz Institute of Molecular Cancer Research Vollzeit

Institute of Molecular Cancer Research_
**Postdoctoral Researcher**

**Your responsibilities**: Maintaining genome stability is crucial for all living cells and organisms. To ensure the fidelity of genome duplication, a complex series of processes has been evolved, known as DNA damage response (DDR), to cope with chromosomal lesions by activating various cell cycle checkpoints, promoting DNA repair system or inducing cell death. The mechanisms underlying the cellular DDR and DNA replication stress are complex and are tightly controlled by post-translational modifications, including phosphorylation, acetylation, methylation, poly (ADP-ribosyl)ation, and modification by ubiquitin and ubiquitin-like proteins.

We recently found that a key event in the DDR is the phosphorylation of ubiquitin, phosphoUb (Walser et at Molecular Cell 2020), quite a new concept in the ubiquitin field. The applicant will be part in this research line, which aims is to investigate the dynamics of phosphoUb modification in cells upon different conditions, and identify the key players - writers, readers and erasers - involved in this novel phosphoUb-based signalling system.

**Your profile**: We are looking for a highly motivated and enthusiastic postdoctoral fellow to join our research group. The applicant is expected to:

- be able to work independently while being a good team player
- hold a PhD in Biochemistry, Biology or related areas
- have a good background in molecular, biochemistry, cellular biology and microscopy
- have prior experience in the broader area of genome stability and ubiquitination
- be first author of at least one high impact peer-reviewed publication

**Place of work**: University of Zurich Irchel, Winterthurerstrasse 190, 8057 Zürich, Switzerland

**Start of employment**: The position is open starting from January 2024 or at a mutually agreed-upon date.

The starting date is flexible, selection will start immediately and continue until the position is filled.


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