Phd Student Position: Elucidating Chaperone Protein

vor 2 Monaten

Basel, Schweiz Universität Basel Vollzeit

The Biomolecular Nano-Dynamics group at the Dept. of Chemistry, University of Basel is looking for a highly talented and motivated PhD student in biophysical chemistry to join our team for the study of protein dynamics and chaperone function using novel techniques, such as single-molecule fluorescence/FRET and unnatural amino-acid labelling.

**Your position**

This PhD project will grow with you. You will create time-resolved direct observations of single Hsp90 chaperone proteins in action, to push beyond static 3D structures and reveal the essential molecular processes that underlie Hsp90's function, i.e.: to assist protein folding and maturation in health and disease. Multiple critical questions remain unsolved in this regard that you can tackle in your PhD. Steps involved:

- Protein construct design, mutagenesis, purification, bioconjugation, quality control
- Single-molecule fluorescence/FRET/DyeCycling experiments
- Genetic code expansion for site-specific unnatural amino-acid labeling
- Data analysis using existing and self-written code

**Your profile**

Prior experience in several of these areas is desired:

- Protein biochemistry (purification, bioconjugation, quality control, etc.)
- Single-molecule experiments and interpretation
- Advanced data analysis, coding, machine learning
- Optics and fluorescence microscopy techniques

Essential requirements:

- MSc degree in (bio-)chemistry, physics, molecular lifesciences with excellent grades
- High motivation and curiosity about fundamental questions in protein science
- Independent analytical thinking and systematic work style
- Excellent experimental problem-solving skills and perseverance
- Friendly team player proficient in English communication (speaking & writing)

**We offer you**
- An exciting and fully funded PhD project in Basel, Switzerland
- Embedding in a productive, interdisciplinary group with an open and interactive lab culture
- State-of-the-art research infrastructure and facilities
- A highly international and interdisciplinary setting stimulating your professional and personal development
- The GRACE graduate center
- A beautiful and very livable city at the intersection of Germany, France, and Switzerland
- Wide-ranging sport offers

**Application / Contact**

Applications are invited before/by **April 7th, 2024**.

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