Phd Student Position: Deciphering The Molecular
vor 8 Monaten
The Biomolecular Nano-Dynamics group at the Dept. of Chemistry, University of Basel is looking for a highly talented and motivated PhD student with a background in (bio-)physics, or biophysical chemistry to join our team for the study of allosteric mechanisms governing recently discovered CRISPR associated proteins using novel techniques, such as single-molecule fluorescence/FRET and nanopore trapping.
**Your position**
This PhD project will grow with you. You will create time-resolved direct observations of single CARF proteins - aka. CRISPR suicide proteins - undergoing allosteric activation, substrate processing, deactivation, etc. How this works, on what timescales, by which conformational rearrangements has not been observed yet in real-time, leaving the underlying molecular processes obscure. In this PhD project, you'll be able to solve (some of) these nanoscale puzzles. Steps involved in the project:
- Single-molecule fluorescence/FRET/DyeCycling experiments
- Solid-state nanopore/NEOtrap experiments
- Advanced data analysis, coding, kinetic modeling
- Protein production and functionalization
**Your profile**
Prior experience in several of these areas is desired:
- Single-molecule experiments and interpretation
- Advanced data analysis, coding, modeling, machine learning
- Optics and fluorescence microscopy and/or nanopore techniques
- Protein biochemistry
Essential requirements:
- MSc degree in physics or (bio-)chemistry with excellent grades
- High motivation and curiosity about fundamental questions on the physical-chemistry of life
- Independent analytical thinking and systematic work style
- Excellent experimental problem-solving skills and perseverance
- Friendly team player proficient in English communication (speaking & writing)
**We offer you**
- An exciting and fully funded PhD project in Basel, Switzerland
- Embedding in a productive, interdisciplinary group with an open and interactive lab culture
- State-of-the-art research infrastructure and facilities
- A highly international and interdisciplinary setting stimulating your professional and personal development
- The GRACE graduate center, wide-ranging sports offers, etc.
- A beautiful and very livable city at the intersection of Germany, France, and Switzerland
**Application / Contact
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