Phd Position to Study The Function of Hot Regions

vor 3 Monaten

Lausanne, Schweiz Université de Lausanne Vollzeit

**Introduction**:
UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, CHUV and Epalinges. As an employer, UNIL encourages excellence, individual recognition and responsibility.

**Presentation**:
**The project**:
HOT regions (High Occupancy Target) in the genome are regions with an unusual High Occupancy of (many) Transcription factors. These regions have been suggested to affect gene expression, but exactly how this works is not clear. We have recently identified HOT regions in the zebrafish genome and these all come together in nuclear space to form a large cluster. This may provide an important clue to the function of HOT regions as these large clusters could provide a source of transcription factors, or conversely, titrate away transcription factors from genes elsewhere in the genome. This has important implications in the context of gene regulation, especially in this early developmental window, when the embryo transitions from a transcriptionally silent to transcriptionally active state. The aim of this project is to investigate (i) how HOT regions seed the formation of TF clusters, (ii) how these clusters come together in nuclear space, and (iii) how HOT regions impact transcription. You will use state of the art sequencing and imaging approaches to address these questions.

**Relevant publications**:
Vastenhouw et al., Development 2019

Pálfy et al., PLoS Genetics 2020

Hilbert et al., Nature Communications 2021

Kuznetsova et al., Current Biology 2023

Ugolini et al., Nature Cell Biology 2024

**Job information**:
Expected start date: as soon as possible

Contract length : 1 year, renewable, max 4 years

Activity rate: 100%

Workplace: University of Lausanne, Dorigny campus

**Your responsibilities**:
Most of your time will be dedicated to research, but you may also be involved in teaching activities (e.g. practical class preparation, literature reading classes, Master project supervision).

**Your qualifications**:

- A Masters degree in any of the life sciences
- Interest in transcription regulation, nuclear organization, quantitative biology
- Experience with genomics and imaging approaches are a plus
- Excellent scientific writing, communication, and interpersonal skills

**What the position offers you**:
You will be supervised by Prof. Nadine Vastenhouw, in a diverse, dynamic, and international research laboratory. You will work on your independent project but there is ample intellectual and technical expertise in the lab to make sure you are well-supported. The working language is English.

The Center for Integrative Genomics encompasses 15 research labs investigating diverse fields related to functional genomics and offers state-of-the-art experimental facilities. Beyond the training in the host laboratory, numerous possibilities exist at UNIL for further professional education and career development.

**Contact for further information**:
To apply, you must upload as a single PDF document:

- A CV, including the names of 3 referees
- A motivation letter in English describing your past research experience and your scientific interests, and how they are a good match for the host laboratory.

Deadline: 1.10.24

**Additional information**:

- UNIL is committed to equal opportunities and diversity._
- UNIL supports early career researchers._

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