Postdoctoral Position in Ion Channel Function

vor 3 Monaten

Lausanne, Schweiz Université de Lausanne Vollzeit

**Introduction**:
UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, CHUV and Epalinges. As an employer, UNIL encourages excellence, individual recognition and responsibility.

**Presentation**:
A postdoctoral position, funded by the Swiss National Science Foundation, is available in the laboratory of Stephan Kellenberger at the Department of biomedical Sciences (DSB) of the University of Lausanne. Our laboratory works towards a molecular understanding of the activation mechanisms of the "acid-sensing ion channels"(ASICs). ASICs are neuronal ion channels involved in pain sensation, the expression of fear, and neurodegeneration after ischemia (for review see Kellenberger and Schild, Pharmacol Rev 67: 1-35, 2015).

**Job information**:
Expected start date in position : December 2024 or January 2025

Contract length : 18 months

Activity rate : 100%

Workplace : Department of Biomedical Sciences Rue du Bugnon 27 1011 Lausanne

**Your responsibilities**:
The postdoctoral fellow will investigate the ASIC activation mechanism with functional approaches, based on predictions from high-resolution structures and from Molecular Dynamics simulations. To this end, she/he will analyze Molecular Dynamics data and use electrophysiological and fluorescent approaches on mostly recombinantly expressed ASICs.

**Your qualifications**:
We are looking for a talented and motivated postdoctoral researcher. Applicants need to have a PhD in life sciences or a related domain. They must have relevant experience with electrophysiology (patch-clamp, two-electrode voltage-clamp) and fluorescence approaches, and ideally be familiar with the analysis of protein structures. Additional desired qualifications are a basic knowledge of molecular biology and biochemistry.

**What the position offers you**:
**Contact for further information**:
Prof. Stephan Kellenberger

Département des Sciences biomédicales

Rue du Bugnon 27 1011 Lausanne

Phone number : 0041 21 692 5422

Applications are invited in the form of a motivation letter, a curriculum vitae, a brief description of research experience and doctoral thesis, and the names and addresses of three academic references, before October 7, 2024.

We thank you for your understanding.

**Additional information**:
For further information, please consult the following publications that illustrate our approaches:
Roy S et al., 2022. Open Biol 12, 10.1098/rsob.220243
Vullo S et al., 2021. eLife 10, 10.7554/eLife.66488

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