Scientist in Proteomics
vor 6 Monaten
**Beschreibung**:
For our international medical partner, F. Hoffmann-La Roche Ltd. in Basel, we are looking for a qualified and motivated **Scientist in Proteomics** for a temporary contract of 12 months with a possible extension.
In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. pRED’s Pharmaceutical Sciences (PS) group enables discovery and development of safe and effective therapeutics at optimal doses in relevant populations with a vision to power translation, continuously improve the accuracy of our predictions and accelerate the development of tomorrow’s medicines. PS supports discovery and development across the whole value chain from target assessment to on-market.
This position is located in the Investigative Safety and Immunosafety (I2S) chapter where we help providing investigative, mechanistic, discovery immuno/safety profiling across experimental platforms. In particular, we strive to develop new approach modalities (NAMs) for the safety profiling of our next generation therapeutics using functionalized cell-based models. We closely collaborate with our therapeutic areas and global functions and we work along agile working principles that assure flexibility, empowerment and distributed leadership.
**Tasks**:
- Organize and conduct proteomics analysis in collaboration with stakeholders in the I2S chapter and from the different therapeutic areas and functions, as needed
- Plan and discuss the experimental strategy with the stakeholders, team members, and data scientists
- Supervise and execute proteomics experiments, including sample preparation, nano LC- MS/MS measurement using high-end mass spectrometric instrumentation, data processing and interpretation
- Provide reports, present and discuss detailed data analysis to the stakeholders in a dynamic and flexible manner
**Must Haves**:
- Ph.D. in analytical chemistry, biochemistry, cell biology or a related field
- A minimum of 3 years experience in proteomics in an academic/industrial environment (post docs)
- Hands-on expertise in nano liquid chromatography - mass-spectrometry based proteomics is mandatory (documented by publication in a peer-reviewed journal). Experience with Orbitrap MS (Q Exactive, Exploris, and/or Tribrids) is essential, and ion mobility (timsTOF Pro, FAIMS Pro) systems is an advantage
- Expertise in quantitative proteomics approaches such as TMT, SILAC, acquisition strategies such as data-independant and -dependant acquisition (DIA, DDA), and targeted approaches such as parallel reaction monitoring (PRM)
- Proficient with common data processing software (Proteome Discoverer, MaxQuant, Spectronaut, PEAKS). Programming (e.g. R/Python) skills are a big plus
- You have excellent verbal and written communication skills in English
**Nice to Haves**:
- Knowledge of Bravo liquid handler
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