Disease Modeling Intern: Target assessment via pathway dynamical modelling and analysis

vor 15 Stunden

Basel, Schweiz F. Hoffmann-La Roche Gruppe Vollzeit

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

Who we are:

This position is located in the Predictive Modeling chapter, within the Pharmaceutical Sciences function, where Disease Modeling (DM) is a primary focus area.

The DM capability is acknowledged as a group of experts in mechanistic modeling, in combining advanced analytics methods (e.g. modeling and machine learning) and in integrating new types of data in our modeling (e.g. -omics, imaging, digital markers, organoids, real-world data). We apply our skills and approaches to projects across all disease therapeutics areas (DTAs) from early to late stage. We build on the strength of being able to integrate pathophysiological and patient disease information into actionable models, thereby informing clinical decisions through heavy use of clinical trial simulations that investigate wide ranges of what-if scenarios.

DM supports the build up of modeling skills in Functions & DTAs by providing relevant training and support to scientists and continues to promote the importance of modeling & simulation for pRED and Roche.

The opportunity:

The objective of this internship is to evaluate the effects of modulating (e.g. inhibiting) a specific biological target by leveraging, improving, and implementing existing pathway models that characterize the target’s activity. These models, typically composed of systems of ordinary differential equations, will serve as the foundation for understanding dynamic behavior under various conditions. To accomplish this, the intern will comprehensively integrate information from various knowledge sources, including public literature as well as Roche’s proprietary preclinical and clinical data.

Who you are:

  • You are a Bachelor’s, Master's or PhD student specializing in computational biology, applied mathematics, or physics, with a focus on systems biology.
  • You have strong programming skills in Matlab, R, Python, and/or Julia.
  • You possess excellent command of the English language, both written and spoken.
  • You are a team player with strong communication skills, a focused work style, and a results-driven mindset.

Your complete application includes the following documents:

  • A Current CV and a Motivation Letter.
  • A certificate of enrollment (if you are currently studying). If you want to use this opportunity to do a Master’s or Diploma thesis, please highlight this in your application.
  • For Non-EU/EFTA citizens: Due to regulations, you must provide a certificate issued by your university stating that an Internship is mandatory for your studies.

Target Start Date: Q1 2025

At Roche, you will have the opportunity to join an established early careers community, with a dedicated Early Careers Forum to share experiences, network and develop a broader understanding of the diverse functions in this pioneering healthcare company. This is a great opportunity to further develop your skills and create meaningful connections with other talents that are launching their careers.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

#J-18808-Ljbffr

  • Disease Modelling Scientist

    vor 2 Wochen

    Basel, Schweiz Hobson Prior Vollzeit

    Hobson Prior are seeking for a Disease Modelling Scientist to join a fantastic pharmaceutical corporation on a contract basis. Our client is focused on providing life-changing remedies for those who suffer from serious illnesses. Please note that to be considered for this role you must have the right to work in this location. **Key Responsibilities**: -...

  • Disease Modeling Scientist

    vor 2 Wochen

    Basel, Schweiz Global Kader Personal Vollzeit

    **INTRODUCTION**: As a preferred supplier for Roche Basel we are looking for an individual as **Disease Modeling Scientist (M/F/d)**: - (contract for 1 year, with possible extension). The earliest start date is within two months, latest start date is 1st May. Remote/Home Office: possible on discussion. **ASSIGNMENT DESCRIPTION**: - Implement parameter...

  • Infectious Disease Modeler

    vor 21 Stunden

    Basel, Schweiz Universität Basel Vollzeit

    The Swiss Tropical and Public Health Institute (Swiss TPH) is a world-leading institute in global health with a particular focus on low - and middle-income countries. Associated with the University of Basel, Swiss TPH combines research, education and services at local, national and international levels. 900 people from 80 nations work at Swiss TPH focusing...

  • Disease Modeling Lead

    vor 2 Wochen

    Basel, Schweiz Coopers Group AG Vollzeit

    **Disease Modeling Lead** For our pharmaceutical client in Basel we are looking for a person who will focus on leading the modeling strategy to support the development of a modeling platform for oncology biomarker research in the area of cancer immunotherapy. **Tasks & Responsibilities**: - Implement parameter inference techniques using the existing model...

  • Professorship Paediatric Infectious and Emerging Diseases Modelling

    Vor 5 Tagen

    Basel, Schweiz ESCMID Academy Working Group Vollzeit

    Professorship Paediatric Infectious and Emerging Diseases Modelling (open-rank) (6024) Type of position offeredThe Faculty of Medicine of the University of Basel is looking to fill the position of Professor of Paediatric Infectious and Emerging Diseases Modelling.Description of position offeredThe successful candidate will develop an internationally...

  • Infectious Disease Modeler

    Vor 5 Tagen

    Basel, Schweiz Universität Basel Vollzeit

    The Swiss Tropical and Public Health Institute (Swiss TPH) is a world-leading institute in global health with a particular focus on low - and middle-income countries. Associated with the University of Basel, Swiss TPH combines research, education and services at local, national and international levels. 900 people from 80 nations work at Swiss TPH focusing...

  • Infectious Disease Modeler

    vor 2 Wochen

    Basel, Schweiz Universität Basel Vollzeit

    The Swiss Tropical and Public Health Institute (Swiss TPH) is a world-leading institute in global health with a particular focus on low - and middle-income countries. Associated with the University of Basel, Swiss TPH combines research, education and services at local, national and international levels. 900 people from 80 nations work at Swiss TPH focusing...

  • Head of Unit Disease Modelling 100%

    Vor 5 Tagen

    Basel, Schweiz Universität Basel Vollzeit

    The Swiss Tropical and Public Health Institute (Swiss TPH) is a world-leading institute in global health with a particular focus on low - and middle-income countries. Associated with the University of Basel, Swiss TPH combines research, education and services at local, national and international levels. 950 people from 95 nations work at Swiss TPH focusing...

  • Director, Pharmacometrics

    vor 7 Monaten

    Basel, Schweiz Certara Vollzeit

    Overview: **About Certara** Certara accelerates medicines using proprietary biosimulation software, technology and services to transform traditional drug discovery and development. Its clients include more than 2,000 biopharmaceutical companies, academic institutions and regulatory agencies across 62 countries. At Certara, we accelerate medicines to...

  • Systems Pharmacology Internship Modelling of Iron

    vor 4 Monaten

    Basel, Schweiz LYO-X GmbH Vollzeit

    Modelling of Iron Metabolism **Project**: Iron is essential for life on Earth and critical for human health. It enables oxygen transport via haemoglobin, supports cellular energy production, and plays a role in enzyme function and detoxification. A lack of iron causes anaemia, leading to fatigue and weakness, while excess iron can result in organ...

  • Svp, Pharmacology and Translational Disease Models

    vor 1 Woche

    Basel, Schweiz Ridgeline Discovery GmbH Vollzeit

    **Ridgeline Discovery is looking for** a SVP, Pharmacology and Translational Disease Models**.** **Ridgeline Discovery **is currently supporting Six Peaks Bio, a newly founded biotech start-up in finding a SVP, Pharmacology and Translational Disease Models. **RESPONSIBILITIES** - In vitro/molecular pharmacology activities - Complex in vitro cell based and...

  • Internship Market Modelling

    vor 1 Tag

    Basel, Schweiz Lonza Vollzeit

    Switzerland, Basel**Internship Market Modelling & Planning**: Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let...

  • Senior Scientist, In Vitro Pharmacology, Metabolic Diseases

    vor 15 Stunden

    Basel, Schweiz Matterhorn Biosciences AG Vollzeit

    SixPeaks Bio is a Versant Ventures and Astra Zeneca funded biotechnology enterprise focused on advancing a portfolio of antibody-based compounds targeting obesity and associated co-morbidities. The company is a preclinical stage company with a pipeline of mAbs as well as mAb-peptide conjugates entering IND preparing studies in the next few months. Our team...

  • Director Business Modeling

    vor 2 Wochen

    Basel, Schweiz Lonza Vollzeit

    Switzerland, Basel Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas,...

  • Manager Licensing Controlling and Divisional Support

    vor 2 Wochen

    Basel, Schweiz Lonza Vollzeit

    Switzerland, Basel- Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas,...

  • Principal Scientist

    vor 2 Wochen

    Basel, Schweiz Novartis Vollzeit

    6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients. - The Disease Area x (DAx) department is accommodated within NIBR and is a group of about 145...

  • Associate Director/director, in Vivo Biology and

    Vor 6 Tagen

    Basel, Schweiz Monte Rosa Therapeutics, Inc Vollzeit

    Overview: Monte Rosa Therapeutics is looking for an experienced, energetic, and self-motivated scientist who will join our team in Basel or Boston to work on the discovery and characterization of novel medicines. At Monte Rosa we are taking a rational approach to targeting disease-causing proteins for degradation by delivering pioneering therapies for...

  • Post Doctorate Scientist in Predictive Modeling

    vor 15 Stunden

    Basel, Schweiz F. Hoffmann-La Roche AG Vollzeit

    Post Doctorate Scientist in Predictive Modeling Post Doctorate Scientist in Predictive Modeling Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare...

  • Cellular and Soluble Biomarkers/bioanalytics

    vor 7 Monaten

    Basel, Schweiz Coopers Group AG Vollzeit

    **Cellular and Soluble Biomarkers/Bioanalytics Project Lead**: You will be part of a team supporting clinical cell-based biomarker implementation in indications where immune cells play a disease relevant role. You will directly contribute to early drug development with your expertise in immunology, flow cytometry and applied cellular biomarker measurement in...

  • Professorship Paediatric Infectious and Emerging

    vor 2 Monaten

    Basel, Schweiz Universität Basel Vollzeit

    **Professorship Paediatric Infectious and Emerging Diseases Modelling (open-rank)** **To be appointed from August 1st 2025 or by arrangement** **Your position** - and middle-income countries. Close collaborations are expected with clinical partners, scientists at the University of Basel and ETH Zurich in Basel, and within the Basel life sciences cluster....