Systems Pharmacology Internship Modelling of Iron
vor 4 Monaten
Modelling of Iron Metabolism
**Project**:
Iron is essential for life on Earth and critical for human health. It enables oxygen transport via haemoglobin, supports cellular energy production, and plays a role in enzyme function and detoxification. A lack of iron causes anaemia, leading to fatigue and weakness, while excess iron can result in organ damage.
**Internship goals**:
- Gaps or areas needing refinement based on current biological understanding and/ or technical considerations are identified.
- A comprehensive structural model of iron metabolism (using ODEs) is developed.
- Validated physiological parameters using Nonlinear Mixed Effects Modelling (with Monolix software) and in-house datasets compiled from literature are estimated.
- Various physiological and pathological conditions, offering new perspectives for drug development in diseases like anaemia and cancer, are simulated.
**Requirements**:
- Bachelor’s or Master’s degree from ETHZ, EPFL or any other recognized university.
- Rigorous, excellent analytical skills
- Confident in understanding, using and numerically solving ordinary differential equations (ODEs)
- Expert in scientific programming using R (or some other closely related scripting language)
- Pro-active and independent work style
- Proficient scientific communication skills
- Proficient in oral and written English
- Strong team player, good communication skills and ability to work with cross-cultural and diverse project teams and clients
**Languages**: English (advanced).
**Location**:Basel.
**Company**:LYO-X is a Swiss company located in Basel providing global consulting and Systems Pharmacology modelling services dedicated to the preclinical and clinical development of biologics and cell-based therapies.
-
Systems Pharmacology Internship Antibiotics
Vor 2 Tagen
Basel, Schweiz LYO-X GmbH VollzeitSimulation software for antibiotics effect prediction **Project**: Antibiotics resistance is a huge issue that is also getting more public awareness due to its criticality. An important part of addressing this problem is the correct usage of antibiotics. For this one has to know if an antibiotic is effective against a certain bacterial strain and how it...
-
Systems Pharmacology Internship Animal-to-human
Vor 2 Tagen
Basel, Schweiz LYO-X GmbH VollzeitSoftware for animal-to-human scaling of biotherapeutics **Project**: Animal-to-human scaling of novel biotherapeutics is an important step in drug development. We want to develop a software that integrates existing data on preclinical and clinical pharmacokinetics of different biotherapeutic formats with mathematical models. The software should be able to...
-
Quantitative Systems Pharmacology Modeler
vor 2 Wochen
Basel, Schweiz LYO-X GmbH VollzeitQuantitative Systems Pharmacology Modeler Are you a highly motivated data scientist and mathematical modeler with a Masters or PhD degree who wants to impact drug development today! If you have great computational skills and are excited to use them to tackle complex biology underlying diseases; then LYO-X is the right place for you! LYO-X is an established...
-
Director Clinical Pharmacology
vor 7 Monaten
Basel, Schweiz Sobi Vollzeit**Company Description** Sobi offers the opportunity to work at an international pharmaceutical company focused on specialty pharmaceuticals meeting the high medical needs of rare disease patients and providing treatment and services to them. Our employees come from a variety of backgrounds within research, healthcare, industry and the academic sphere. **Key...
-
Director, Clinical Pharmacology
vor 1 Woche
Basel, Schweiz Luzsana Biotechnology (Part of Hengrui) Vollzeit**Job Title**: Director, Clinical Pharmacology **Reports to (Title)**: Department Head of Clinical Pharmacology & Early Development **Location**: Basel Switzerland **Direct Reports**: TBD **Department**: Clinical Pharmacology & Early Development Luzsana Biotechnology (Luzsana), is a global, purpose-driven innovative medicines company committed to...
-
Director, Clinical Pharmacology
vor 1 Woche
Basel, Schweiz Luzsana Biotechnology (Part of Hengrui) Vollzeit**Job Title**: Director, Clinical Pharmacology **Reports to (Title)**: Department Head of Clinical Pharmacology & Early Development **Location**: Basel Switzerland **Direct Reports**: TBD **Department**: Clinical Pharmacology & Early Development Luzsana Biotechnology (Luzsana) is a global, purpose-driven innovative medicines company with the mission to...
-
Disease Modelling Scientist
vor 1 Woche
Basel, Schweiz Hobson Prior VollzeitHobson Prior are seeking for a Disease Modelling Scientist to join a fantastic pharmaceutical corporation on a contract basis. Our client is focused on providing life-changing remedies for those who suffer from serious illnesses. Please note that to be considered for this role you must have the right to work in this location. **Key Responsibilities**: -...
-
Director, Clinical Pharmacology
vor 1 Woche
Basel, Schweiz Hengrui Europe Therapeutics AG Vollzeit**Job Title**: Director, Clinical Pharmacology **Reports to (Title)**: Department Head of Clinical Pharmacology & Early Development **Location**: Basel Switzerland **Direct Reports**: TBD **Department**: Clinical Pharmacology & Early Development **About Hengrui**: The Hengrui ex-China organization drives the development and commercialization of the...
-
Clinical Pharmacology Scientist
vor 1 Woche
Basel, Schweiz Global Kader Personal Vollzeit**EINFÜHRUNG**: As a preferred supplier for Roche Basel, we are looking for an individual as **Clinical Pharmacology Scientist**: - (contract for 2 years duration, with possible extension). The earliest start date is asap or within 3 months. An office set up with possibility for Homeoffice will be provided. **AUFGABENBESCHREIBUNG**: - Responsible for...
-
Clinical Pharmacology Scientist
vor 1 Woche
Basel, Schweiz Proclinical VollzeitProclinical are recruiting Clinical Pharmacology Scientist for an international business. This is a contract role and is located in Basel, with the availability to work remotely from home. Our client is focused on detecting innovative remedies. **Responsibilities**: - Accountable for the scientific aspects of clinical pharmacology study protocol...
-
Director Clinical Pharmacology/pharmacometrics
Vor 2 Tagen
Basel, Schweiz Hengrui USA Vollzeit**Reports to (Title): Department Head of Clinical Pharmacology & Early Development** **Location: Basel Switzerland** **Direct Reports : TBD** **Department: Clinical Pharmacology & Early Development** **Job Summary**: **Essential Job Functions**: - Oversees all clinical pharmacology activities related to pre-IND, IND, phase1-3, PK, PK/PD and regulatory...
-
Internship in Pharmacometrics
vor 7 Monaten
Basel, Schweiz Novartis Vollzeit391082BR **Internship in Pharmacometrics**: Switzerland **About the role** At Novartis, we are reimagining medicine to improve and extend people's lives. We have one of the most diverse product pipelines in the pharmaceutical industry and performance-driven professionals are bringing innovative medicines to life. The department of Pharmacometrics at...
-
Director Clinical Pharmacology
Vor 7 Tagen
Basel, Schweiz Coopers Group AG Vollzeit**Director Clincial Pharmacology** The role: This role has a significant impact on the company's products, by supporting clinical execution of Clinical Pharmacology studies clinical development programs in accordance with the Clinical Development Plan and Clinical Pharmacology Plan. **Responsibilities**: - Overall accountability for clinical pharmacology...
-
Translational Pkpd
vor 1 Woche
Basel, Schweiz Hobson Prior VollzeitHobson Prior are currently seeking a Translational PKPD & Clinical Pharmacology Scientist to join a brilliant pharmaceutical organisation on a contract basis located in Basel. Our client is focused on discovering new remedies and diagnostics. Please note that to be considered for this role you must have the right to work in this location. **Key...
-
Business Development Manager
vor 1 Woche
Basel, Schweiz Iron Mountain VollzeitAt Iron Mountain we know that work, when done well, makes a positive impact for our customers, our employees, and our planet. That’s why we need smart, committed people to join us. Whether you’re looking to start your career or make a change, talk to us and see how you can elevate the power of your work at Iron Mountain.We provide expert, sustainable...
-
Head of Unit Disease Modelling 100%
vor 22 Stunden
Basel, Schweiz Universität Basel VollzeitThe Swiss Tropical and Public Health Institute (Swiss TPH) is a world-leading institute in global health with a particular focus on low - and middle-income countries. Associated with the University of Basel, Swiss TPH combines research, education and services at local, national and international levels. 950 people from 95 nations work at Swiss TPH focusing...
-
Clinical Pharmacology Statistician
vor 21 Stunden
Basel, Schweiz Idorsia Pharmaceuticals Ltd. Vollzeit**About Idorsia Pharmaceuticals Ltd** Idorsia Ltd is reaching out for more - We have more ideas, we see more opportunities and we want to help more patients. In order to achieve this, we want to develop Idorsia into one of Europe’s leading biopharmaceutical companies, with a strong scientific core. Headquartered in Switzerland - a European biotech hub -...
-
Post-doc Cns Pharmacology
vor 2 Wochen
Basel, Schweiz Idorsia Pharmaceuticals Ltd. Vollzeit**About Idorsia Pharmaceuticals Ltd** Idorsia Ltd is reaching out for more - We have more ideas, we see more opportunities and we want to help more patients. In order to achieve this, we want to develop Idorsia into one of Europe’s leading biopharmaceutical companies, with a strong scientific core. Headquartered in Switzerland - a European biotech hub -...
-
Basel, Schweiz Ridgeline Discovery GmbH Vollzeit**Ridgeline Discovery is looking for** a SVP, Pharmacology and Translational Disease Models**.** **Ridgeline Discovery **is currently supporting Six Peaks Bio, a newly founded biotech start-up in finding a SVP, Pharmacology and Translational Disease Models. **RESPONSIBILITIES** - In vitro/molecular pharmacology activities - Complex in vitro cell based and...
-
Research Associate In-vivo Pharmacology
vor 7 Monaten
Basel, Schweiz We make it VollzeitBeschreibung: We make it GmbH is a company operating nationally in Switzerland, which has a high level of competence in the personnel services sector thanks to many years of successful experience. Concentration of placement activities on the core areas of industry, technology, office/administration, engineering, pharmaceuticals and IT. We make it GmbH...