Senior Scientist, In Vitro Pharmacology, Metabolic Diseases

vor 19 Stunden

Basel, Schweiz Matterhorn Biosciences AG Vollzeit
SixPeaks Bio is a Versant Ventures and Astra Zeneca funded biotechnology enterprise focused on advancing a portfolio of antibody-based compounds targeting obesity and associated co-morbidities. The company is a preclinical stage company with a pipeline of mAbs as well as mAb-peptide conjugates entering IND preparing studies in the next few months. Our team is passionate about science and committed to improving patient outcomes through cutting-edge research and clinical trials.

The Senior Scientist In Vitro Pharmacology, Metabolic Diseases will be responsible for the in vitro strategy and related assays to support target validation and PD assessment of SixPeaks Bio’s pipeline. As a member of the Nonclinical and Translational Development Team, you will be responsible for internal assay development, experimental design/execution and data analysis from target assessment to IND, as well as serve as an external alliances manager for in vitro-related outsourced activities. The individual in this position will have the unique opportunity to participate in the rapid growth of a biotech startup.

RESPONSIBILITIES
  1. You collaboratively design, execute and critically interpret complex in vitro preclinical experimental activities for the validation and characterization of targets or therapeutic agents.
  2. You direct and/or perform in vitro / ex vivo experimental work to support the evaluation of the lead candidates.
  3. You develop -from scratch- complex in vitro models to address MoA-relevant questions in the most predictive way.
  4. You coordinate in vitro activities internally and with external partners; You guide the selection of preferred provider(s) for outsourced in vitro studies; You manage external providers as scientific and organizational point person.
  5. You innovatively (1) use appropriate tools for data visualization, (2) apply statistical methods and machine learning algorithms to build predictive models, and (3) leverage real-world data (RWD) to competitively position assets.
  6. You are accountable for the integrative analysis, review, interpretation and reporting of IND-enabling activities.
  7. You act as subject matter expert in project teams and demonstrate clear and professional verbal and written communication.
  8. You build a network of external expertise and are well-connected to the drivers of new and emerging scientific innovation and technologies in a fast-progressing field.
  9. You work independently, analyzing and presenting data in a timely and highly efficient manner to project teams and stakeholders.
QUALIFICATIONS
  1. You have a Ph.D., in Life Sciences and 5-8 years of experience in biomedical research and/or drug development.
  2. You have drug development experience in the metabolic / musculoskeletal disease areas.
  3. You have hands-on experience with standard and more complex in vitro and ex vivo models, and associated readouts in the metabolism and musculoskeletal disease areas.
  4. You master tools to support advanced data visualization, analysis, integration; you are familiar with statistical methods and machine learning algorithms.
  5. You have excellent data management and record-keeping skills.
  6. You have experience in the back-translation of clinical data, which is a significant plus.
  7. You are a fast learner and willing to learn new skills and technologies; you are flexible and can accommodate to rapidly changing priorities and deadlines.
  8. You have a track-record of working with CROs, academic partners, and external expert consultants.
  9. You have excellent oral and written communication skills with high attention to critical details and proven ability to collaborate effectively in cross-functional teams and influence decision-making process.
PERSONAL QUALITIES
  1. Highly motivated self-starter with a can-do attitude and passion for working in a dynamic, interactive, fast-paced, innovative, and entrepreneurial environment.
  2. Proven ability to build, maintain and influence effective working relationships with key internal and external stakeholders.
  3. People management – direct and indirect reports.
  4. Good planning skills and strength in delivering outputs on agreed timelines.
  5. Able to work both independently as well as part of a team.
WHAT WE CURRENTLY OFFER
  1. People: We are an international and diverse team with talented and passionate people.
  2. Creativity: We offer an innovative and creative environment.
  3. Development: We support the individual development of our employees.
  4. Fun: From time-to-time we organise cool off-site summer and winter team events.
  5. Offices: Our well-equipped laboratories and offices are located at the Tech Park, a premier address for early-stage start-ups in Basel.
  6. Commuter Benefits: We support our employees tailored to their personal needs in commuting to work and offer parking facilities or a commuter contribution.
  7. Flexible Working: We support flexible working as appropriate.
  8. Christmas Closure: In addition to the 24 holidays per year, our offices/labs are closed between Christmas and New Year.
  9. Birthday Retreat: On top of that, your birthday is your personal holiday - our employees enjoy their birthday with a day off.
  10. Food: We like get-togethers during lunch time. Enjoy tasty, subsidised meals from our FELFEL food fridge.
  11. Coffee: Meet up with your colleagues and grab free coffee.

Would you like to play a pivotal role in developing innovative therapies that could revolutionize the treatment of obesity and cardiometabolic conditions?

To apply, please submit your completed application form along with your CV, cover letter, and reference letters.

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