Scientist 3D CNS Model

Gefunden in: Talent CH C2 - vor 2 Wochen


Basel, Schweiz Roche Vollzeit

The Position

In Roche´s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. 

Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

You will join Roche’s Institute of Human Biology (IHB), an organization within pRED whose goal is to harness and advance the use of human model systems in drug discovery and development, as well as personalized medicine. Our interdisciplinary research bridges academic and pharmaceutical research, connecting biologists, engineers, and data scientists. We partner and collaborate with leading scientific institutions worldwide to tackle grand challenges by assembling, funding, and leading interdisciplinary teams of experts to work on highly ambitious and complex scientific questions.

Role Mission

In close collaboration with the Neurosciences and Rare Disease (NRD) Discovery Translation Area within pRED, we are looking for an independent and highly motivated scientist to join our team at the interface of academic and translational research. The scientist will play a key role in developing and applying patient-relevant human model systems that recapitulate protein aggregates characteristic of Alzheimer’s disease. Our vision is to establish foundational in vitro technology for drug profiling by synergizing with the unparalleled expertise at the IHB to investigate poorly understood clinical findings and address the needs of the future NRD portfolio.

Your Impact

Develop a 3D co-culture model of the brain, incorporating neurons and glia. 

Establish imaging-based assays to measure glial function in 3D co-culture models 

Thoroughly characterize cell lines with disease-relevant mutations

Independently design, execute, analyze, interpret and communicate experiments 

Demonstrate scientific excellence by publishing and presenting at scientific meetings

Your Profile

PhD in Bioengineering, Neuroscience or other relevant areas

Hands-on expertise on stem-cell derived models of human brain cell types 

Experience working with hydrogel-based 3D culture models

Experience developing imaging-based functional assays including image quantification workflows

Knowledge of cellular mechanisms driving disease pathology in Alzheimer’s disease 

Strong critical thinking, communication, organization, and presentation skills.

Ability to navigate in a matrix environment to effectively influence, advise, or consult experts to jointly move projects forward

Driven by scientific curiosity and commitment to patients

Temporary position for 2 years.

Reporting line to: Sonja Kleinlogel, NRD

Our commitment

Roche commits to recognising talent and aptitude. We prioritize encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.



  • Basel, Schweiz Coopers Group AG Vollzeit

    **Research Associate for 3D CNS in **vitro models** Tasks & Responsibilities: - Independently design, execute and interpret experimental data - You will be responsible for the generation, maintenance and characterization of 2D and 3D iPSC cell cultures - Analyze brain organoids on a morphological (including High Content Imaging), biochemical and functional...


  • Basel, Schweiz Global Kader Personal Vollzeit

    **EINFÜHRUNG**: As a preferred supplier for Roche Basel, we are looking for an individual as **Research Associate for 3D CNS in vitro models**: (contract for 1 year, with possible extension). The earliest start date is within 2 months. **AUFGABENBESCHREIBUNG**: - Independently design, execute and interpret experimental data - You will be responsible for...

  • Principal Scientist

    vor 2 Wochen


    Basel, Schweiz Batterman Consulting Basel AG Vollzeit

    **Our Client** **Principal Scientist****: **Your responsibilities** - Provide key biology expertise and leadership for defined programs throughout discovery and development stages - Identify and design experimental work plans to address program needs at various stages - Participation in scientific review and assessment of potential new and/or existing...

  • Data Scientist

    Vor 3 Tagen


    Basel, Schweiz Coopers Group AG Vollzeit

    Data Scientist For our client, a leading company in the Pharmaceutical industry, we are currently looking for a**:Data Scientist** **Background**: expertise (oncology/cardiology/laboratory data/) to develop high-quality code aiming to explore biomedical data sources as well as create the associated machine learning models able to support clinical decision...


  • Basel, Schweiz Work Selection Vollzeit

    **Beschreibung**: For our international medical partner, F. Hoffmann-La Roche Ltd. in Basel, we are looking for a qualified and motivated **DMPK/ PD Data Scientist** for a temporary contract of 12 months. - and back-end IT infrastructure related to planning, execution, analysis, and database curation of non-clinical pharmacokinetic (PK) and...


  • Basel, Schweiz Novartis Vollzeit

    395156BR **Snr Principal Scientist Translational Research/Immunology (80-100%*)**: Switzerland **About the role** Location: Basel, Switzerland Full time, onsite, #LI-Onsite The Immunology Department (IMM-DA) at Novartis has a strong track record in discovery and development of novel therapies for the treatment of autoimmune and inflammatory diseases. We...

  • Data Scientist

    Vor 3 Tagen


    Basel, Schweiz ITech Consult Vollzeit

    **Data Scientist (M/F/d) - quantitative modeling / real-world healthcare data / Python, R / ML / continuous integration / version control systems / Communications Skills / English** **Project**: For our customer a big pharmaceutical company in Basel we are looking for a highly qualified Data Scientist (M/F/d). **Background**: **Tasks &...

  • Data Scientist

    Vor 3 Tagen


    Basel, Schweiz Work Selection Vollzeit

    **Beschreibung**: For our international medical partner, F. Hoffmann-La Roche Ltd. in Basel, we are looking for a qualified and motivated **Data Scientist** for a temporary contract of 12 months with a possible extension. **Tasks**: - Develop predictive algorithms using real world clinical data (electronic medical records) to address clinical needs - Work...

  • Discovery Scientist in Ophthalmology

    Gefunden in: Talent CH C2 - vor 2 Wochen


    Basel, Schweiz Roche Vollzeit

    The Position In Roche’sPharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility...


  • Basel, Schweiz Universität Basel Vollzeit

    The Skin Biology Laboratory (Prof. A. Navarini) is looking for a PhD student to study the mechanisms of chronic inflammatory skin diseases. We have recently developed human epidermal organoids, a 3D epidermis model, to recapitulate the biology and functions of a human epidermis. This innovative model allows us to study in vitro the impact of defective genes...

  • Data Scientist

    Gefunden in: beBee S CH - vor 3 Wochen


    Basel, Schweiz wega Vollzeit

    We are a Pharma and Life Science IT service provider that has been successfully carrying out 'state-of-the-art' projects for international customers for more than 30 years, now. Our consultants work in our office in Basel from home on our customer’s premises We are a dynamic forward-thinking and expanding organization with a great team spirit and...

  • Student Internship IP2TIS 2024

    Gefunden in: beBee S CH - vor 4 Wochen


    Basel, Basel-City, Schweiz F. Hoffmann-La Roche AG Vollzeit

    The Position Join our dynamic team at Roche and contribute to meaningful initiatives in sustainability and innovation. Our Global Internship Programme in Innovation & Sustainability #IP2TIS offers a unique opportunity for passionate individuals to gain hands-on experience in the pharmaceutical industry while making a positive impact on the world. As a...

  • Data Scientist

    Vor 5 Tagen


    Basel, Schweiz Spiden Vollzeit

    **About Spiden**: What could you build on top of real-time and non-invasive Glucose monitoring? That is what Spiden is all about, and we want to beat Apple at it: Machine learning, personalized health, and predictive medicine. If these areas resonate with you, join us to work on foundational technologic and scientific challenges at Spiden. We are a Swiss...

  • Data Scientist

    Vor 5 Tagen


    Basel, Schweiz Artifact Vollzeit

    **Description** AI brings huge potential, but many companies are still struggling to release the desired impact. We are a pragmatic and dynamic team to help “accelerating impact with Data Science” for our business clients. You as a talent are needed to rapidly grow our business which started up from three founders with proven track-records in AI...


  • Basel, Schweiz Novartis Vollzeit

    250! The number of genomics research projects that are waiting for your data analysis expertise every year. Your work will be important towards faster discovery and development of next generation breakthrough therapies for unmet medical need. - The Autoimmunity, Transplantation and Inflammation (ATI) Disease Area at the Novartis Institutes for BioMedical...

  • Research Associate in Neurogenomics

    Gefunden in: beBee jobs CH - vor 2 Wochen


    Basel, Basel-Stadt, Schweiz F. Hoffmann-La Roche AG Vollzeit

    Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people's varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche,...


  • Basel, Schweiz Universität Basel Vollzeit

    **Your position** - Independent project management - Independent planning and design of experiments including mouse experiments - Primary cell culture models and animal models to study mechanisms of sialic acid/Siglec-mediated immune suppression in cancer - Supervision of a technician working on the project - Direct interaction with the Biotech partner in...


  • Basel, Schweiz The Biozentrum, University of Basel Vollzeit

    Your position Research position with clinical involvement as part of a Swiss National Science Foundation (SNSF) project “Learning-based 3D Infant Face and Head Model for Medical Applications”. You will be part of the


  • Basel, Schweiz Universität Basel Vollzeit

    **Your position** - Perform experiments under the supervision of an experienced scientist - Independent analysis and performance of experiments including mouse experiments - Primary cell culture models and animal models to study mechanisms of sialic acid/Siglec-mediated immune suppression in cancer - The position is available from January 2023 on **Your...


  • Basel, Basel-Stadt, Schweiz Universität Basel Vollzeit

    Clinical Research Position in Paediatric Oral and Cranio-Maxillofacial Surgery University Hospital BaselApplicants are invited for a 1-year full-time research position in paediatric craniofacial malformations at the Clinic for Oral and Cranio-Maxillofacial Surgery, University Hospital Basel. The starting date can be or by arrangement.Your position Research...