Principal Scientist
vor 4 Wochen
**Our Client**
**Principal Scientist****:
**Your responsibilities**
- Provide key biology expertise and leadership for defined programs throughout discovery and development stages
- Identify and design experimental work plans to address program needs at various stages
- Participation in scientific review and assessment of potential new and/or existing programs
- Design and lead cell-based and molecular biology strategies (e.g., qPCR, CRISPR, shRNA or siRNA, minigene reporters, mutagenesis) for target validation, high and medium throughput screenings, and MoA studies
- Review technical publications, articles and abstracts
- Summarize/report data, generate presentation and documentation materials, and present work at meetings
- Participate in multi-disciplinary project team meetings and serve as the key biology representative for defined programs
- Work cross-functionally with the Biology, Chemistry, Preclinical Development, and Platform teams to meet ambitious program and company goals
- Effectively lead and manage work conducted at CROs to establish and execute externalized assays and analyse data
**Your Profile**
- Doctoral degree in molecular biology, biochemistry or related field
- Expertise in cancer biology and/or immunology and associated models, cellular assays and molecular databases is highly preferred
- Minimum 10 years of combined R&D experience from the biotech/biopharmaceutical industry and world-class academic institutions with experience gained in drug development team settings
- Track record of successful progression of drug development programs from initial drug discovery through pre-clinical development (experience in small-molecule development is ideal)
- Experience in RNA splicing/RNA biology and RNA-based techniques (such as qRT-PCR, RNA FISH, protein-RNA/DNA co-localization, RNA CLIP) are highly desirable
- Working knowledge of CRISPR-based cell line generation and iPSC derived human disease models is desirable
- Familiarity with next generation sequencing approaches including RNAseq
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