Senior Lab Manager

Vor 6 Tagen

Lausanne, Waadt, Schweiz EPM Scientific Vollzeit

Location:
Vaud canton, Switzerland

Employment Type:
Permanent

We are seeking an experienced scientific leader to oversee and advance mass‑spectrometry-based metabolomics operations. This senior position carries significant responsibility for ensuring high‑quality data generation, operational excellence, and the development of robust analytical workflows in a dynamic research and development environment.

What You Will Do

  • Lead all day‑to‑day operations of a high‑performance metabolomics laboratory, including method development, validation, scheduling, capacity planning, vendor management, and EHS oversight
  • Manage both targeted and untargeted metabolomics workflows from sample intake through preparation, LC‑MS/MS/IMS analysis, QA/QC, and reporting
  • Serve as the key point of contact for scientific, operational, and strategic lab‑related topics
  • Oversee biomarker discovery activities, ensuring sound study design, rigorous QC practices, and adherence to timelines
  • Drive molecular identification efforts using MS/MS libraries and complementary analytical approaches
  • Define and maintain data standards, integrating analytical software tools and basic scripting for QC and workflow optimization (e.g., MS‑DIAL, Skyline, vendor platforms, R/Python)
  • Ensure high instrument uptime through strategic preventive and corrective maintenance planning
  • Build and maintain SOPs, training materials, and operational documentation to support quality and future regulatory alignment
  • Lead, mentor, and develop a team of scientists, fostering a culture of accountability, scientific rigor, and operational efficiency
  • Ensure consistent documentation practices and reliable use of electronic lab notebooks (ELN)
  • Manage resource allocation, project priorities, and reporting to ensure smooth operational flow

Your Profile

  • 7+ years managing mass‑spectrometry operations in metabolomics, biotech, pharma, or
    CRO environments
  • Deep expertise with LC‑MS/MS (QTOF preferred), feature extraction pipelines, and targeted quantification methods
  • Skilled with metabolomics data tools (e.g., MS‑DIAL, XCMS, Skyline, MassHunter) and basic scripting (R/Python)
  • Experience in biomarker discovery, metabolite identification, and multi‑matrix sample preparation
  • Strong documentation and SOP development skills; familiarity with evolving quality frameworks
  • Proven leadership abilities and comfort working in dynamic, fast‑paced environments

Nice to Have

  • Experience with clinical sample workflows, biobanks, or chain‑of‑custody processes
  • Exposure to orthogonal identification technologies (e.g., proteomics, glycomics, IR‑based tools)
  • Background using DoE for method optimization

Ready to Make an Impact?

If you are a scientifically driven, hands‑on leader looking to shape high‑quality metabolomics operations, we encourage you to apply.

Please submit your CV.

Only candidates eligible to work in Switzerland can be considered.
Only selected candidates will be contacted.

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