Systems Pharmacology Internship Modelling of Iron

Vor 3 Tagen

Basel, Schweiz LYO-X GmbH Vollzeit

Modelling of Iron Metabolism

**Project**:
Iron is essential for life on Earth and critical for human health. It enables oxygen transport via haemoglobin, supports cellular energy production, and plays a role in enzyme function and detoxification. A lack of iron causes anaemia, leading to fatigue and weakness, while excess iron can result in organ damage.

**Internship goals**:

- Gaps or areas needing refinement based on current biological understanding and/ or technical considerations are identified.
- A comprehensive structural model of iron metabolism (using ODEs) is developed.
- Validated physiological parameters using Nonlinear Mixed Effects Modelling (with Monolix software) and in-house datasets compiled from literature are estimated.
- Various physiological and pathological conditions, offering new perspectives for drug development in diseases like anaemia and cancer, are simulated.

**Requirements**:

- Bachelor’s or Master’s degree from ETHZ, EPFL or any other recognized university.
- Rigorous, excellent analytical skills
- Confident in understanding, using and numerically solving ordinary differential equations (ODEs)
- Expert in scientific programming using R (or some other closely related scripting language)
- Pro-active and independent work style
- Proficient scientific communication skills
- Proficient in oral and written English
- Strong team player, good communication skills and ability to work with cross-cultural and diverse project teams and clients

**Languages**: English (advanced).

**Location**:Basel.

**Company**:LYO-X is a Swiss company located in Basel providing global consulting and Systems Pharmacology modelling services dedicated to the preclinical and clinical development of biologics and cell-based therapies.

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