Postdoc position in the development of in vitro models of the BBB to investigate the efficacy of innovative biotherapeutics against CNS diseases
vor 5 Stunden
Job description In this project, we aim at exploring how in vitro models can be leveraged to improve preclinical drug selection, in particular for gene therapy development. Building on the group expertise in blood-brain-barrier platforms, the postdoc will develop new in vitro models of the human and mouse blood-brain-barrier and benchmark the in vitro models for preclinical and clinical investigations. After validation of the models, the postdoc will work in close collaboration with researchers at Novartis AG to test whether the developed models can be used to expedite the selection of candidate therapeutics, in particular for gene therapy. Your profile The successful candidateshould have a background in bioengineering and biotechnology or related fields, with a preference for experience with microfluidics and advanced in vitro models, transport across endothelial barriers, and viral vectors. Experience in optical microscopy is highly beneficial. Further, knowledge of standard molecular biology techniques and NGS technologies will be considered advantageous for this position. Good communication skills and a proactive work attitude are required for working in the interdisciplinary field of preclinical testing and drug development. The Postdoc must be able to fluently communicate in English (oral and written) and be willing to work in a highly interactive and collaborative international environment. The researcher will work at the intersection of academic and industrial research with access to resources and expertise from both institutions. Academic excellence, a professional work attitude, and a self-driven nature are expected. The position is fully funded for initially 2 years, an extension to up to 4 years is possible. The starting date is flexible but must be before 10-.
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Basel, Schweiz Bio Engineering Laboratory & Novartis VollzeitJob description In this project, we aim at exploring how in vitro models can be leveraged to improve preclinical drug selection, in particular for gene therapy development. Building on the group expertise in blood-brain-barrier platforms, the postdoc will develop new in vitro models of the human and mouse blood-brain-barrier and benchmark the in vitro models...
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Basel, Schweiz Bio Engineering Laboratory & Novartis VollzeitJob description The postdoc will develop new cell-culture platforms and tisssue models intended to mimic the kidney microenvironment. He will use these platforms to culture stem-cell-derived renal cells to realize a renal tubular unit. The postdoc will then focus on the functional characterization of the tubular unit to confirm that the developed model...
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Internship at The Interface of Biomedical
Vor 7 Tagen
Basel, Schweiz Institute of Molecular and Clinical Ophthalmology Basel VollzeitThe Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking a highly motivated **Intern **to take part of a medical device development in the context of gene therapy within the Ophthalmic Translational Research Group. IOB is a research institute combining basic and clinical research. Its mission is to drive innovations in understanding...
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Basel, Schweiz The Biozentrum, University of Basel VollzeitYour position In an interdisciplinary project supported by a Sinergia grant of the Swiss National Science Foundation, we investigate the molecular underpinnings of gene regulation in muscle plasticity at the atomic level. At the center of this regulation lies PGC-1α, a transcriptional co-activator and master regulator of metabolic processes. PGC-1α...
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Basel, Schweiz Friedrich Miescher Institute VollzeitThe group of Prisca Liberali at the Friedrich Miescher Institute for Biomedical Research (FMI) investigates the collective properties and patterning of multicellular systems. Their research focuses on how such properties arise from single-cell behavior and their self-organization, in order to elucidate fundamental biological processes. The Disease of Aging...
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Professor of Ophthalmology
Vor 3 Tagen
Basel, Schweiz The Biozentrum, University of Basel VollzeitYour position You are responsible for the eye clinic of the University Hospital Basel -with respect to the medical, financial, and organizational management.With your clinical expertise and your background in research, you will strengthen the national and international visibility of Ophthalmology at the University of Basel. You will apply your clinical...
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Professor of Ophthalmology
vor 5 Stunden
Basel, Schweiz The Biozentrum, University of Basel VollzeitYour position You are responsible for the eye clinic of the University Hospital Basel -with respect to the medical, financial, and organizational management.With your clinical expertise and your background in research, you will strengthen the national and international visibility of Ophthalmology at the University of Basel. You will apply your clinical...
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Basel, Schweiz The Biozentrum, University of Basel VollzeitYour position Elucidating signal transduction involving GPCR, cytokine-, immunoglobulin downstream signaling involved in an inflammatory and metabolic network.Functional immune cell / phenotypic / response output assays and biomarker detection /identification in vitro and in vivo.Determining immune cell responses via FACS, high content imaging microscopy,...
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Basel, Schweiz The Biozentrum, University of Basel VollzeitYour position Elucidating signal transduction involving GPCR, cytokine-, immunoglobulin downstream signaling involved in an inflammatory and metabolic network. Functional immune cell / phenotypic / response output assays and biomarker detection /identification in vitro and in vivo. Determining immune cell responses via FACS, high content imaging microscopy,...
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Head of Immunology
vor 1 Tag
Basel, Basel-Stadt, Schweiz Ridgeline Discovery GmbH VollzeitRidgeline Discovery, a Versant Ventures Discovery Engine, creates and operates Versant-financed innovative biotech companies in partnership with entrepreneurs, industry, and leading academics across Europe. In recent years, Ridgeline has assembled an international team of >50 highly experienced drug discovery and industry professionals and built and operated...
