Postdoctoral Position in Structural Biology and Biophysics
vor 3 Wochen
Your position In an interdisciplinary project supported by a Sinergia grant of the Swiss National Science Foundation, we investigate the molecular underpinnings of gene regulation in muscle plasticity at the atomic level. At the center of this regulation lies PGC-1α, a transcriptional co-activator and master regulator of metabolic processes. PGC-1α dysfunction has been linked to obesity, diabetes, muscular dystrophies, neurodegenerative diseases, and cancer. Despite its importance, the molecular mechanisms by which PGC-1α—a large, predominantly disordered protein with only a single structured RRM domain-senses cellular metabolic states and translates this information into transcriptional activation remain elusive. This postdoctoral project aims to unravel the molecular mechanisms of PGC-1α function by combining advanced biophysical methods, with a particular emphasis on NMR spectroscopy for structural and dynamic insights into intrinsically disordered proteins, as well as complementary biophysical approaches to characterize protein function and interaction. By applying these techniques, we seek to uncover how PGC-1α integrates signals to regulate transcription, providing fundamental insights into metabolism and disease. The work is a close collaboration with the group of Prof. Christoph Handschin, complementing our structural research with genetic elucidation of structure-function aspects, spanning from molecular biology to animal physiology. Your profile Required PhD in Biochemistry, Biophysics, Structural Biology, or a related field Strong background in protein science and / or biophysical methods Interest in intrinsically disordered proteins, transcriptional regulation, and molecular mechanisms of disease High motivation to learn, apply and develop advanced NMR spectroscopy Excellent communication skills and ability to thrive in a collaborative environment Desirable Experience with NMR spectroscopy Excellent wet lab skills in protein production and biochemical assays Programming / data analysis skills (e.g., Python, MATLAB) #J-18808-Ljbffr
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Postdoctoral Position
vor 1 Woche
Basel, Basel-Stadt, Schweiz Universität Basel Vollzeit CHF 60'000 - CHF 90'000 pro JahrHow does life emerge from molecules and cells? This is the central question that motivates us. With curiosity and passion, we investigate the entire spectrum ranging from the atom to the organism. The Biozentrum of the University of Basel is one of the world's leading life sciences institutes. With 32 groups and 500 employees, we are a dynamic and...
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Basel, Schweiz Friedrich Miescher Institute VollzeitThe is hiring a tenure-track group leader (assistant professor level) in Structural Biology. We are looking for an innovative scientist with a research program focused on mechanistic questions that are related to genome regulation, RNA metabolism, or protein homeostasis. We are especially interested in candidates using cutting-edge structural biology...
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Basel, Schweiz Universität Basel VollzeitThe Department of Pharmaceutical Sciences of the University of Basel is an Academic Drug Discovery & Development Center, which comprehensively covers academic drug research throughout pre-clinical and clinical research phases. The Pharmaceutical Biology Group (Head Prof. Robin Teufel) within the Department is searching for a postdoctoral researcher with...
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Basel, Schweiz Universität Basel VollzeitHow does life emerge from molecules and cells? This is the central question that motivates us. With curiosity and passion, we investigate the entire spectrum ranging from the atom to the organism. The Biozentrum of the University of Basel is one of the world's leading life sciences institutes. With 31 groups and 500 employees, we are a dynamic and...
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Basel, Schweiz RFCSR VollzeitOverviewOrganization: ETH Zürich, Department of Biosystems Science and Engineering Location: Basel, SwitzerlandETH Zürich invites applications for a Postdoctoral Fellow to advance synthetic biology approaches for engineering microbial and mammalian systems. The fellow will contribute to developing new genetic circuits, biosensors, and therapeutic...
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Postdoctoral in Generative Models of
vor 1 Woche
Basel, Schweiz Friedrich Miescher Institute VollzeitThe group of Dr. Guillaume Diss at the Friedrich Miescher Institute for Biomedical Research (FMI) aims to study the genetic architecture of protein function — specifically, how the sequence of a protein determines its function. Recent advances in artificial intelligence and generative biology have paved the way for such developments. However, training...
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Postdoctoral Fellow in Biochemistry
vor 1 Woche
Basel, Schweiz Monte Rosa Therapeutics VollzeitMonte Rosa Therapeutics is seeking a motivated and talented Postdoctoral Scientist to join our Biomolecular sciences group at Monte Rosa. In this role, you will contribute to the success of our Quantitative and Engineered Elimination of Neosubstrates (QuEEN) platform with expertise in molecular biology and biochemistry. Experience or knowledge in proteomics...
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Basel, Schweiz Scholarships VollzeitOverviewThe Department of Biomedicine at the University of Basel is offering a Postdoctoral Position in Bone Marrow Tissue Engineering. The project, funded by the Swiss National Science Foundation, focuses on developing 3D human bone marrow tissue models to study and improve hematopoiesis.The University of Basel, founded in 1460, is Switzerland’s oldest...
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Postdoctoral Position
vor 1 Woche
Basel, Schweiz Universität Basel VollzeitThe Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine,...
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Assistant/associate Professor in Molecular
vor 2 Wochen
Basel, Schweiz Universität Basel Vollzeit**Your position** **We offer** We offer a very generous research endowment and state-of-the art core facilities. The Biozentrum consists of 30 research groups and 250 postdoctoral fellows and graduate students from more than 50 countries researching in fields ranging from structural, computational, cellular and developmental biology to microbiology and...
