Postdoc position in the development of in vitro models of the BBB to investigate the efficacy of innovative biotherapeutics against CNS diseases
vor 1 Woche
Job description In this project, we aim at exploring how in vitro models can be leveraged to improve preclinical drug selection, in particular for gene therapy development. Building on the group expertise in blood-brain-barrier platforms, the postdoc will develop new in vitro models of the human and mouse blood-brain-barrier and benchmark the in vitro models for preclinical and clinical investigations. After validation of the models, the postdoc will work in close collaboration with researchers at Novartis AG to test whether the developed models can be used to expedite the selection of candidate therapeutics, in particular for gene therapy. Your profile The successful candidateshould have a background in bioengineering and biotechnology or related fields, with a preference for experience with microfluidics and advanced in vitro models, transport across endothelial barriers, and viral vectors. Experience in optical microscopy is highly beneficial. Further, knowledge of standard molecular biology techniques and NGS technologies will be considered advantageous for this position. Good communication skills and a proactive work attitude are required for working in the interdisciplinary field of preclinical testing and drug development. The Postdoc must be able to fluently communicate in English (oral and written) and be willing to work in a highly interactive and collaborative international environment. The researcher will work at the intersection of academic and industrial research with access to resources and expertise from both institutions. Academic excellence, a professional work attitude, and a self-driven nature are expected. The position is fully funded for initially 2 years, an extension to up to 4 years is possible. The starting date is flexible but must be before 10-.
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Internship at The Interface of Biomedical
Vor 2 Tagen
Basel, Schweiz Institute of Molecular and Clinical Ophthalmology Basel VollzeitThe Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking a highly motivated **Intern **to take part of a medical device development in the context of gene therapy within the Ophthalmic Translational Research Group. IOB is a research institute combining basic and clinical research. Its mission is to drive innovations in understanding...
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Basel, Schweiz The Biozentrum, University of Basel VollzeitYour position In an interdisciplinary project supported by a Sinergia grant of the Swiss National Science Foundation, we investigate the molecular underpinnings of gene regulation in muscle plasticity at the atomic level. At the center of this regulation lies PGC-1α, a transcriptional co-activator and master regulator of metabolic processes. PGC-1α...
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Basel, Schweiz Friedrich Miescher Institute VollzeitThe group of Prisca Liberali at the Friedrich Miescher Institute for Biomedical Research (FMI) investigates the collective properties and patterning of multicellular systems. Their research focuses on how such properties arise from single-cell behavior and their self-organization, in order to elucidate fundamental biological processes. The Disease of Aging...
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Basel, Schweiz The Biozentrum, University of Basel VollzeitYour position Elucidating signal transduction involving GPCR, cytokine-, immunoglobulin downstream signaling involved in an inflammatory and metabolic network.Functional immune cell / phenotypic / response output assays and biomarker detection /identification in vitro and in vivo.Determining immune cell responses via FACS, high content imaging microscopy,...
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Phd Position in The Field of Archaeobotany
vor 1 Woche
Basel, Schweiz Universität Basel Vollzeit**PhD position in the field of archaeobotany** **100% / starting August 2025, latest possible starting date October 2025** **Your position** **Your profile** **We offer you** - 3-year 100% PhD position, hosted by the IPAS in the Department of Environmental Sciences at the University of Basel, Switzerland - Research travel and conference budget -...
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Basel, Schweiz Universität Basel VollzeitA position is available in the Brain Tumor Immunotherapy and Biology Lab at the Department of Biomedicine (DBM) in Basel, Switzerland. The successful candidate will work on developing cellular therapies against glioblastoma and brain metastasis. The project focus is on the genetic modification of T cells and macrophages with next-generation armored CARs. Lab...
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Ph.d. Position at The Department of Biomedical
vor 2 Wochen
Basel, Schweiz Universität Basel Vollzeit**Your position** - Study the behavior of cells seeded on novel materials focusing on biocompatibility, tissue phenotype, and matrix deposition - Development of an osteoarthritic model based on a paper-microfluidic device - Study of drug diffusion and cellular responses in real-time using electrochemical sensors **Your profile** - Preferably a master's...
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Basel, Schweiz The Biozentrum, University of Basel VollzeitYour position The successful candidate will focus on physiological innovations related to sterols and will (i) identify their composition and distribution among species, (ii) examine genomes for positive selection to detect sterol-related innovations and associated genes, and (iii) assess sterol functions and the underlying genetic networks through...
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Research Associate for 3D Cns in Vitro Models
vor 4 Stunden
Basel, Schweiz Coopers Group AG Vollzeit**Research Associate for 3D CNS in **vitro models** Tasks & Responsibilities: - Independently design, execute and interpret experimental data - You will be responsible for the generation, maintenance and characterization of 2D and 3D iPSC cell cultures - Analyze brain organoids on a morphological (including High Content Imaging), biochemical and functional...
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Postdoctoral and Phd Student Positions in The
Vor 6 Tagen
Basel, Schweiz Universität Basel VollzeitThe Department of Biomedicine is a joint venture of the University of Basel and the University Hospitals of Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. The Department fosters curiosity-driven and interdisciplinary...
