LC-MS Bioanalytical Assay Developer for Oligonucleotide and Small Molecule Therapeutics

vor 2 Wochen

basel, Schweiz Roche Vollzeit

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche. At Roche's Pharmaceutical Research and Early Development (pRED), we transform science into medicines to address some of the world's toughest unmet healthcare needs. Guided by curiosity, responsibility, and humility, we empower our people to deliver life-changing innovations quickly. This role is based at the Roche Innovation Center Basel within the Pharmaceutical Sciences (PS) function, focused on developing regulatory-compliant assays for biomarkers and bioanalytics in close collaboration with therapeutic areas and functions. The position is part of the cross-functional RNAHub, where experts across biology, engineering, and data science collaborate to apply RNA-targeting technologies for drug, biomarker, and target discovery. The RNAHub's data-driven approach blends artificial and human intelligence, fostering a collaborative, innovative research community. The Opportunity As an expert in the development of bioanalytical and biomarker assays required for the development of oligonucleotides and small molecules, your main responsibilities are the evaluation, development, and application of novel methodologies to analyze and quantify oligonucleotides and challenging small molecules from animal and human study samples. You are applying highly sensitive LC-MS methods in which you have special expert knowledge. You work with scientists and associates to support the development of oligonucleotides and small molecules from discovery to early development. You have knowledge in the field of bioanalytical and biomarker assay development in the lab with special focus on oligonucleotides and small molecules; you develop new sensitive methods to assess the pharmacokinetics of a therapeutic compound and its biodistribution as well as selected biomarkers / pharmacodynamic markers. You are an expert at applying LC-MS technologies in the lab, evaluating new technologies and helping to

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