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Biotech Researcher

vor 2 Wochen


Basel, Basel-Stadt, Schweiz Matterhorn Biosciences AG Vollzeit

Matterhorn Biosciences AG is redefining drug discovery through innovative approaches to protein degradation. Our team has identified key ligases that govern the turnover of hard-to-drug transcription factors and convert these pairs into druggable protein-protein interfaces. With an initial focus on oncology and immune modulation, we are committed to advancing highly impactful precision medicines across multiple disease areas.

We are seeking a Senior Research Associate to join our drug discovery and screening team. The successful candidate will have profound experience in small molecule screening using cell-based as well as biochemical assays. Profound experience in the field of induced proximity and targeted protein degradation technologies is a strong plus. Your role will be to develop and optimize various key assays and execute screens with Matterhorn's library and screening setup.

You are a highly motivated and enthusiastic team player with proven organizational skills and a strong scientific background to impact our early target discovery pipeline and later stage lead optimization campaigns.

This position offers a tremendous opportunity to support one of Versant Ventures' latest portfolio companies in an experienced, vibrant, and dynamic biotech team.

Responsibilities
  • Implement cellular and biochemical assays for screening in close collaboration with the biology team
  • Optimize screening assays to identify hits for targeted drug discovery programs, focusing on validation for robustness, sensitivity, specificity, and reproducibility
  • Run implemented screening assays at Matterhorn for both small-scale screens and regular compound profiling
  • Contribute to day-to-day operations enabling efficient execution and quality of screening results
  • Establish and troubleshoot novel screening technologies in collaboration with the biology team, ensuring optimal performance of equipment and protocols, and supporting the integration of screening hardware and compound logistics
  • Be an integral part of the screening environment working closely with medicinal chemistry and biology experts to execute assays and generate screening results
  • Analyze and document experimental data utilizing dedicated software, databases, and lab journals, and present results in internal meetings