Senior Research Associate& Assay Development and Screening

Vor 5 Tagen

Basel, Basel-Stadt, Schweiz Ridgeline Discovery GmbH Vollzeit

Zenith Therapeutics is redefining drug discovery through a new approach to protein degradation. Our team has identified key ligases that govern the turnover of hard-to-drug transcription factors and convert these pairs into druggable protein-protein interfaces. With an initial focus on oncology and immune modulation, we are committed to advancing highly impactful precision medicines across multiple disease areas.


Headquartered in Basel, Switzerland, Zenith was created by Ridgeline Discovery, a Versant Ventures Discovery Engine, and is backed by leading investors in the biotech sector.


We are looking for a highly motivated Senior Research Associate joining Zenith's drug discovery and screening team. The successful candidate will have profound experience in small molecule screening using cell-based as well as biochemical assays. Profound experience in the field of induced proximity and targeted protein degradation technologies is a strong plus. Your role will be to develop and optimize a variety of key assays and execute screens with Zenith's library and screening setup.


You are a highly motivated and enthusiastic team player with proven organizational skills and with a strong scientific background to impact our early target discovery pipeline and later stage lead optimization campaigns. 

This Basel-based position offers a tremendous opportunity to support one of Versant Ventures' latest portfolio companies in an experienced, vibrant, and dynamic biotech team.

RESPONSIBILITIES

  • Cellular and biochemical assay implementation for screening in close collaboration with the biology team
  • Optimize screening assays to identify hits for targeted drug discovery programs, with a particular focus on validation for robustness, sensitivity, specificity, and reproducibility
  • Run the implemented screening assays at Zenith for both small-scale screens and regular compound profiling
  • Contribute to day-to-day operations enabling efficient execution and quality of screening results
  • Establish and troubleshoot novel screening technologies in close collaboration with the biology team, ensuring optimal performance of equipment and protocols, support with integration of screening hardware as well as compound logistics
  • Be an integral part of the screening environment working closely with medicinal chemistry and biology experts, to execute assays and generate screening results
  • Thorough analysis and documentation of experimental data utilizing dedicated software, databases and lab journals, and presentation of results in internal meetings

QUALIFICATIONS

You are a highly motivated and independent individual with excellent communication and interpersonal skills who is effective at working in a collaborative and inclusive environment.

  • Laboratory apprenticeship or BS / MS in biotechnology, biochemistry, biology, or a related field with at least 3 years of hands-on experience in small molecule screening using cellular and biochemical assays in an industry setting or screening facility
  • Experience with high-capacity, cell-based and biochemical assays and familiar with experimental design and implementation for screening and follow up data evaluation with strong attention to detail and excellent organizational and problem-solving skills
  • Experience with protein-protein interaction, induced proximity and targeted protein degradation technologies in cells such as e.g. nanoBRET, 2-hybrid systems, split protein technologies, HiBIT & Luciferase assays
  • Software Proficiency: Skilled with Microsoft Office (Word, PowerPoint, Excel) and GraphPad Prism, Spotfire, Genedata Screener or similar analysis tools; experience with compound databases and screening analysis software.
  • Effective communicator and strong collaborator in diverse team settings, with excellent interpersonal skills
  • Proficiency in English, both spoken and written

WHAT WE CURRENTLY OFFER

  • People: We are an international and diverse team with talented and passionate people.
  • Creativity: We offer an innovative and creative environment.
  • Development: We support the individual development of our employees.
  • Fun: From time-to-time we organise cool off-site summer and winter team events.
  • Offices: Our well-equipped laboratories and offices are located at the Tech Park, a premier address for early-stage start-ups in Basel.
  • Commuter Benefits: We support our employees tailored to their personal needs in commuting to work and offer parking facilities or a commuter contribution.
  • Flexible Working: We support flexible working as appropriate.
  • Christmas Closure: In addition to the 24 holidays per year, our offices/labs are closed between Christmas and New Year.
  • Birthday Retreat: On top of that, your birthday is your personal holiday - our employees enjoy their birthday with a day off.
  • Food: We like get-togethers during lunch time. Enjoy tasty, subsidised meals from our FELFEL food fridge.
  • Coffee: Meet up with your colleagues and grab free coffee.

To apply, please submit your completed application form along with your CV, cover letter, and reference letters (Arbeitszeugnisse).

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