Senior Optical Microscopy Specialist

Vor 2 Tagen


Basel, Basel-Stadt, Schweiz Roche Vollzeit
About Roche

Roche is a world-leading research-focused healthcare group, with more than 100,000 employees across 100 countries. Our success is built on innovation, curiosity, and diversity.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche. As an equal opportunity employer, we welcome applications from talented individuals who share our values.

The Opportunity

The Institute for Human Biology (IHB) is a newly established research center in Basel, Switzerland, dedicated to advancing human biology through the use of human model systems for translational research. We are seeking an optical microscopy expert to join its team to provide dedicated training and support to the IHB. The successful candidate will have a strong theoretical and practical background in the use of state-of-the-art optical microscopy techniques. Candidates with a solid understanding of how to best design and execute optical microscopy-based assays as applied to a variety of 2D and 3D sample types (including complex organoid cultures and fixed cell/tissue preparations) are strongly desired. The successful candidate will operate as a part of a matrix team, collaborating closely with scientists from the IHB, as well as contributing to the implementation and growth of the Microscopy Technology Platform within the pRED organization.

- Provide in-depth training to platform users in the appropriate use of both optical microscope instrumentation and fluorescence-based microscopy approaches;

- Support platform users in the planning, development, execution, and validation of both routine and custom workflows with regards to fluorescence microscopy-based assays and experiments, as well as engage with stakeholders to present and discuss findings in a dynamic and flexible manner;

- Ensure the continued production of high-quality FAIR research data by performing regular quality control and troubleshooting of optical microscopy instruments and workflows;

- Embrace a continuous learning mindset by actively engaging with the scientific literature to stay abreast of emergent technologies/approaches in the advanced optical microscopy field.

Key Requirements

- Hold a PhD degree in biology, chemistry, or a related field with a minimum of 3-5 years of professional experience focused on fluorescence-based optical microscopy approaches, either in an academic setting and/or the pharmaceutical industry/biotech sector;

- Possess in-depth theoretical and proven hands-on knowledge in a variety of optical microscopy techniques and their adaptation across various biological sample types. Specifically, robust experience in the use of widefield microscopy, confocal microscopy (both laser-scanning and live-cell spinning disk), light-sheet microscopy, and non-linear approaches such as multi-photon/label-free Raman imaging is required. Additional familiarity with super-resolution microscopy methods would be considered a plus;

- Proven ability to collaborate within and across matrix teams, including molecular biologists, microscopists, research histopathologists, and image analysis experts, educating scientists on optical microscopy instruments and workflows, as well as in designing experiments based on complex research questions, including interpretation of results.

What We Offer

At Roche, we offer a dynamic work environment that allows you to grow and develop your skills. We are committed to attracting and retaining talented individuals who share our values. In addition to competitive compensation and benefits, we offer extensive development and training opportunities, flexible working options, and a comprehensive employee program.

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