Head of Large Molecule Research

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position As the Head of Large Molecule Research (LMR), you will lead a critical function within Roche Pharma Research and Development (pRED), reporting directly to the Head of Therapeutic Modalities (TMo). You will oversee a global function of approximately 350 scientists located at our Penzberg site.In this high-visibility executive role, you are accountable for the entire lifecycle of protein therapeutics generation from initial target assessment through to entry-into-human studies. You will collaborate closely with the Head of Nucleic Acid Based Medicines and the Head of Small Molecule Research to deliver gene therapies and antibody-conjugates. You will operate embedded within a global research and technical development environment, driving discovery research, external innovation, molecule characterization, process research, and program management. Your Impact - Develop and implement the global large molecule strategy in alignment with Therapeutic Modalities and pRED’s long-term objectives and in consultation with fellow leaders. - Lead the end-to-end generation of protein therapeutics for Discovery and Translational Areas (DTAs), ensuring successful progression from target assessment to the start of clinical phases. - Ensure the delivery of non-GMP material for preclinical studies and the manufacturing of GMP material for Phase I studies. - Champion research excellence and the continuous advancement of core technologies to ensure the function remains at the forefront of innovation. - Ensure highest standards in project and portfolio decisions and alignment with pRED portfolio strategy and ambitions. - Spearhead innovative concepts and strategies for the identification of new therapeutic compounds. - Manage the critical interface between LMR and pRED DTAs, and Pharma Technical to ensure the seamless transfer of projects and processes. - Collaborate with the Leaders of Nucleic-Acid-Based Medicines and Small Molecule Research to deliver on gene therapies and complex antibody-conjugates. - Ensure strict compliance with all industry regulations, safety guidelines, and Roche corporate standards across the function. Who You Are - You are a strategic leader capable of holding joint accountability for the development of the modality strategy in pRED. - You thrive in a collaborative environment, acting as a member of the Therapeutic Modalities leadership team and various governance committees. - You are passionate about human potential. You will select, develop, and evaluate scientists and leaders to ensure the efficient operation and continuous development of the LMR function. - You are dedicated to fostering a culture of safety, environmental protection, and regulatory compliance. - Success in this role requires close collaboration with the Pharma Technical Development organization. - You will actively manage the interface with Pharma Technical to guarantee the successful transfer of our innovations into tangible medical solutions. Who we are A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let’s build a healthier future, together. Roche is an Equal Opportunity Employer.