Phd Student Position to Study Effects of The
vor 2 Monaten
**PhD student position to study effects of the neurite outgrowth inhibitor NogoA in neurodegeneration**:
A PhD student position is available at the University of Bern, Switzerland, to join the research group of Meike Mevissen (Vet. Pharmacology & Toxicology).
A leading area of pharmaceutical research is based on neuroscience therapeutics with vast resources applied to the discovery and development of drugs for disorders in the central nervous system (CNS). According to the World Health Organization (WHO), 8 out of 10 disorders in the 3 highest disability classes are neurological problems and they account for about 12% of deaths worldwide. Parkinson's disease (PD) is a multifactorial neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Despite the severity of the disease and the rapidly increasing prevalence of PD, the pathogenesis of PD is not sufficiently understood, the therapy is mostly symptomatic, and there are no treatments to cure the disease or slow down the progression of the neurodegeneration. It is therefore crucial to better define the mechanisms leading to the disease and identify targets for therapeutical intervention.
The neurite growth inhibitor A (NogoA) was found to co-localize with dopaminergic neurons in the substantia nigra (SNpc) of the brain. Antagonization of NogoA was shown to increase survival of transplanted human dopaminergic neurons in a PD rat model, suggesting a role of NogoA in PD. Based on these findings, we therefore created NogoA-deficient (RTN4-KO) cells. The RTN4-KO clone showed a significant reduction of α-synuclein and a visual tendency of more dopaminergic neurons. In this project, we will address the effects of NogoA during neuronal development and neurodegeneration using unique 2D and 3D models that we have established. These analyses will be complemented by the quantitative assessment of key players in cellular pathways involved in neuronal differentiation and degeneration and mitochondrial function.
**In the scope of this PhD position**, we intend to use a variety of advanced models and biochemical, genetic, state-of-the-art microscopy technologies of stem cell
- and neuronal-markers combined with high-content analysis, and functional approaches to understand the impact of the neurite growth inhibitors NogoA in neuronal development and neurodegeneration. To this purpose, we use various model systems, including wild-type and disease models, and CRISPR-Cas9-created NogoA-deficient 2D cell lines and 3D midbrain organoids suitable for investigating the effects of NogoA in neuronal development and neurodegeneration.
**We offer** a young and enthusiastic research group, state-of-the art research facilities at the attractive working location in Bern. The remuneration is in accordance with the Swiss National Science Foundation (SNSF) regulations (annual brutto salary of CHF 47,040 - 50,040).
This position is a 3-4 year appointment and is available from September 1st, 2023 onwards.
Wir haben weitere aktuelle Stellen in diesem Bereich, die Sie unten finden können
-
Phd Student Position to Study Effects of The
Vor 6 Tagen
Bern, Bern, Schweiz Universität Bern Universität Bern VollzeitPhD student position to study effects of the neurite outgrowth inhibitor NogoA in neurodegeneration:A PhD student position is available at the University of Bern, Switzerland, to join the research group of Meike Mevissen (Vet. Pharmacology & Toxicology).A leading area of pharmaceutical research is based on neuroscience therapeutics with vast resources...
-
Phd Student Position
vor 3 Wochen
Bern, Schweiz Universität Bern Universität Bern Vollzeit**PhD Student Position**: **Workplace**: Department of Ophthalmology, Inselspital, University of Bern **Project Title**: Organoid-based modelling of human retinal degeneration / regeneration The Department of Ophthalmology is offering a PhD student position in the field of neuroscience/cell biology. The group's research interest is focused on the...
-
Phd Student Position
Vor 6 Tagen
Bern, Bern, Schweiz Universität Bern Universität Bern VollzeitPhD Student Position:Workplace: Department of Ophthalmology, Inselspital, University of BernProject Title: Organoid-based modelling of human retinal degeneration / regenerationThe Department of Ophthalmology is offering a PhD student position in the field of neuroscience/cell biology. The group's research interest is focused on the pathophysiology of the...
-
Phd Student
vor 3 Wochen
Bern, Schweiz Universität Bern Universität Bern Vollzeit**PhD Student (full position)**: At the Institute of Communication and Media Studies (ikmb) of the University of Bern, a position is available as a PhD Student (full position). The position will be available from July 1st, 2023 (or by appointment) for an initial period of three and half years. It is intended to serve the purpose of scientific...
-
Phd Student Position
vor 3 Wochen
Bern, Schweiz Universität Bern Vollzeit**Workplace**: Department of Ophthalmology, Inselspital, University of Bern **Project Title**: Organoid-based modelling of human retinal degeneration / regeneration The Department of Ophthalmology is offering a PhD student position in the field of neuroscience/cell biology. The group's research interest is focused on the pathophysiology of the retina. The...
-
Phd Student Position in Space Research
vor 1 Woche
Bern, Schweiz Universität Bern Universität Bern Vollzeit**PhD student position in Space Research & Instrumentation**: The Space Research and Planetology Division of the University of Bern is the leading planetary sciences institute in Switzerland and participates in numerous ESA and NASA missions. The Division has a long-standing tradition in space research starting from the solar wind sail placed on the Moon...
-
Phd or Md-phd Student: Diagnosis and Prognosis of
vor 2 Monaten
Bern, Schweiz Universität Bern Universität Bern Vollzeit**PhD or MD-PhD student: diagnosis and prognosis of childhood asthma** **Institute of Social and Preventive Medicine (ISPM) at the University of Bern**: The Child and Adolescent Health group, headed by Prof. Dr. med. Claudia Kuehni conducts population-based and clinical studies in child health. **Would you like to understand and improve healthcare for...
-
Phd or Md-phd Student: Diagnosis and Prognosis of
vor 3 Wochen
Bern, Schweiz Universität Bern Universität Bern Vollzeit**PhD or MD-PhD student: diagnosis and prognosis of childhood asthma** **Institute of Social and Preventive Medicine (ISPM) at the University of Bern**: The Child and Adolescent Health group, headed by Prof. Dr. med. Claudia Kuehni conducts population-based and clinical studies in child health. **Would you like to understand and improve healthcare for...
-
Phd Student Position in Space Research
Vor 6 Tagen
Bern, Bern, Schweiz Universität Bern Universität Bern VollzeitPhD student position in Space Research & Instrumentation:The Space Research and Planetology Division of the University of Bern is the leading planetary sciences institute in Switzerland and participates in numerous ESA and NASA missions. The Division has a long-standing tradition in space research starting from the solar wind sail placed on the Moon during...
-
Phd Student
vor 3 Wochen
Bern, Schweiz Universität Bern VollzeitAt the Institute of Communication and Media Studies (ikmb) of the University of Bern, a position is available as a PhD Student (full position). The position will be available from July 1st, 2023 (or by appointment) for an initial period of three and half years. It is intended to serve the purpose of scientific qualification. Tasks - Conducting research in...
-
Phd or Md-phd Student: Diagnosis and Prognosis of
vor 2 Monaten
Bern, Schweiz Universität Bern VollzeitThe Child and Adolescent Health group, headed by Prof. Dr. med. Claudia Kuehni conducts population-based and clinical studies in child health. **Would you like to understand and improve healthcare for children with asthma? Develop prognostic models for predicting the disease course? Conduct a participatory research study, with patients' families and...
-
Phd or Md-phd Student: Diagnosis and Prognosis of
vor 3 Wochen
Bern, Schweiz Universität Bern VollzeitThe Child and Adolescent Health group, headed by Prof. Dr. med. Claudia Kuehni conducts population-based and clinical studies in child health. **Would you like to understand and improve healthcare for children with asthma? Develop prognostic models for predicting the disease course? Conduct a participatory research study, with patients' families and...
-
Phd Student Position
Vor 6 Tagen
Bern, Bern, Schweiz Universität Bern VollzeitWorkplace: Department of Ophthalmology, Inselspital, University of BernProject Title: Organoid-based modelling of human retinal degeneration / regenerationThe Department of Ophthalmology is offering a PhD student position in the field of neuroscience/cell biology. The group's research interest is focused on the pathophysiology of the retina. The newly opened...
-
Phd Student Position in Neurology
vor 3 Wochen
Bern, Schweiz Universität Bern Universität Bern Vollzeit**PhD student position in Neurology** **100 %**: Institution: Division of Clinical Neurology, Vetsuisse Faculty, University Bern, Switzerland Start of Employment: 1st March 2024 (or by agreement) Fixed term: 3.5 years The Division of Clinical Neurology has an open position as PhD for a project together with the Division of Neurological Sciences (Anna...
-
Bern, Bern, Schweiz Universität Bern Universität Bern VollzeitPhD or MD-PhD student: diagnosis and prognosis of childhood asthmaInstitute of Social and Preventive Medicine (ISPM) at the University of Bern:The Child and Adolescent Health group, headed by Prof. Dr. med. Claudia Kuehni conducts population-based and clinical studies in child health.Would you like to understand and improve healthcare for children with...
-
Phd Student Position in Space Research
vor 2 Wochen
Bern, Schweiz Universität Bern Universität Bern Vollzeit**PhD student position in Space Research & Instrumentation**: The Space Research and Planetology Division of the University of Bern is the leading planetary sciences institute in Switzerland and participates in numerous ESA and NASA missions. The Division has a long-standing tradition in space research starting from the solar wind sail placed on the Moon...
-
Phd Student
vor 2 Monaten
Bern, Schweiz Universität Bern Vollzeit**PhD Student (full position)** At the Institute of Communication and Media Studies (ikmb) of the University of Bern, a position is available as a PhD Student (full position). The position will be available from July 1st, 2023 (or by appointment) for an initial period of three and half years. It is intended to serve the purpose of scientific...
-
Phd Student Position in Neurology
Vor 6 Tagen
Bern, Bern, Schweiz Universität Bern Universität Bern VollzeitPhD student position in Neurology100 %:Institution: Division of Clinical Neurology, Vetsuisse Faculty, University Bern, SwitzerlandStart of Employment: 1st March 2024 (or by agreement)Fixed term: 3.5 yearsThe Division of Clinical Neurology has an open position as PhD for a project together with the Division of Neurological Sciences (Anna Oevermann)...
-
Phd Student Position “ultrafast Investigation of
vor 3 Wochen
Bern, Schweiz Universität Bern Universität Bern Vollzeit**PhD student position “Ultrafast Investigation of Anti-Kasha Photochemical Reactions in Molecular Systems"** **100 %**: Institute of Applied Physics, University of Bern Tasks **Requirements**: We offer We are offering a fully funded position as a doctoral fellow (PhD student) in our group at the Institute of Applied Physics of the University of Bern...
-
Phd Student Position in Space Research
vor 1 Woche
Bern, Schweiz Universität Bern VollzeitThe Space Research and Planetology Division of the University of Bern is the leading planetary sciences institute in Switzerland and participates in numerous ESA and NASA missions. The Division has a long-standing tradition in space research starting from the solar wind sail placed on the Moon during the Apollo program, recent missions such as Rosetta to...
