Phd Student: Targeting Drug-tolerant Persister
vor 1 Monat
**PhD student: Targeting drug-tolerant persister cells - an early offensive against acquired drug resistance in pancreatic neuroendocrine tumors**
**100%**:
The Institute of Tissue Medicine and Pathology (ITMP) is an institution of the University of Bern, Switzerland with three major tasks: teaching, research and diagnostic service. In total, there are around 190 employees at the Institute. The ITMP provides an attractive setting to perform cutting-edge translational research in direct collaboration with pathologists and oncologists treating patients.
As of 1st september 2023 or by arrangement, the research group of Perren/Marinoni/Sadowski of the Division of Experimental Pathology is seeking a PhD student: Targeting drug-tolerant persister cells - an early offensive against acquired drug resistance in pancreatic neuroendocrine tumors
Job description
The group's research focusses on epigenetic and metabolic changes that underpin progression of indolent PanNET to aggressive, metastatic cancer. Treatment of aggressive PanNET is challenging due to the heterogeneity of this disease, the limited number of treatment options and the inevitable development of acquired drug resistance (ADR). ADR is estimated to account for 90% of cancer mortality and affects all types of therapies (chemo, targeted, immune and radiation). Targeting the early stages of ADR is a promising new strategy to extend the efficacy of existing therapies. Increasing evidence, including our own work (Tousignant et al, 2020; doi.org/10.1186/s40170-020-00217-6), shows that drug-tolerant persister (DTP) cells might play a critical role during the early phases of ADR.
**Requirements**:
**Offer**:
Application
For further information, please contact Ms Cornelia Mileto (cornelia.mileto
e.ch).
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