Phd Student in Organs-on-chip
Vor 6 Tagen
**PhD Student in Organs-on-Chip**:
The Organs-on-Chip Technologies (OOC) Lab at the ARTORG Center for Biomedical Engineering Research of the University of Bern focuses on the development of advanced in-vitro models (organs-on-chip) by combining engineering, microfluidics, microtechnologies and cell biology. We currently have an open position for a PhD Student in Organs-on-Chip development of a pulmonary arterial hypertension (PAH)-on-chip model.
Pulmonary arterial hypertension (PAH) is a rare cardiopulmonary disease with a poor prognosis and few therapeutic options. Current PAH drugs can slow down, but not reverse disease progression, which is driven by chronic vascular remodeling. The aim of this PhD project is to develop a PAH-on-chip model able to mimic the vascular remodeling dynamics and the underlying multicellular crosstalk to address fundamental questions regarding the mechanisms that drive lung vascular remodeling in PAH. The project is a collaboration with the Charité University Hospital in Berlin, Germany.
Qualifications:
We are looking for an exceptional applicant with ideally a multidisciplinary background including microfluidics, mechanics, and cell biology. The applicant is expected to have the following knowledge and skills:
- Applicants must hold a MSc degree in Mechanical Eng., Microsystems Eng., Biomedical Eng. or equivalent
- Practical experience in designing and characterizing microfluidic chips and set-ups (CAD, numerical simulation)
- Excellent theoretical understanding of microfluidic and fluid mechanics phenomena
- Practical experience of cell culture in microfluidic systems & fluorescence microscopy (incl. software Fiji,...) is a plus
- Enjoys setting up and conducting experimental skills (microfluidic set-up, microfluidic characterization and cell culture experiments)
- Very good oral and written communication skills in English are required.
Personal skills:
The applicant must have a creative and committed personality, good organizational skills, the ability to work autonomously, but willing to perform and interact efficiently within a multidisciplinary team.
What we offer:
- A friendly, stimulating, international and multidisciplinary environment.
- A workplace in Bern, Switzerland's capital, known for its high quality of life and surrounded by beautiful nature, perfect for hiking, biking, swimming and winter sports.
How to apply:
References: (1) Bichsel et al., Tissue Engineering Part A 21 (15-16), 2166-2176, (2) Zeinali et al., APL Bioeng. 2021 Apr 2;5(2):026102.
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