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Phd Student in The Field of Targeting The

vor 1 Monat

Schweiz ETH Zurich Vollzeit

19/01/2023

**Job Information**:
**Organisation/Company**
- ETH Zurich**Research Field**
- Chemistry » Biochemistry- Biological sciences » Other- Chemistry » Other- Pharmacological sciences » Other**Researcher Profile**
- First Stage Researcher (R1)**Country**
- Switzerland**Application Deadline**
- 24/03/2023 - 23:59 (UTC)**Type of Contract**
- Temporary**Job Status**
- Part-time**Hours Per Week**
- 38**Is the job funded through the EU Research Framework Programme?**
- Not funded by an EU programme**Is the Job related to staff position within a Research Infrastructure?**
- No**Offer Description**:
PhD Student in the field of targeting the microenvironment**Project background**:

- Radiopharmaceuticals are used in clinical practice for targeted diagnosis and therapy of various cancers. Most compounds target membrane proteins that are often overexpressed in cancer cells. However, this approach is limited to specific cancer types for each compound. Therefore, we would like to develop a broader approach so that one compound can be used for different cancer types. The altering mechanism in the microenvironment is in different cancer types very similar and is also valid for other diseases. In this SNSF-funded project, we will investigate different radiolabeled compounds as novel target proteins in the microenvironment and evaluate their potential for diagnosis and therapy.**Job description**:
The second PhD student will take care of the in vitro and in vivo evaluation of these compounds. The goal is to test the compounds for their therapeutic and diagnostic capabilities in different mouse models and to understand the role of the target protein in cancer tissue. Evaluating the effects of targeted radiotherapy directed to the microenvironment is of great interest. For this purpose, different methods such as SPECT/CT, high-end fluorescence microscopy as well as proteomic approaches can be used.

The two students will work closely with different Swiss and international research groups. Additionally, you will be involved in laboratory management and teaching. The students will be hired via PSI and the working place can be PSI and ETHZ. The PhD degree will be awarded by the ETHZ.

**Your profile**:

- We expect that you have a Master degree in Chemistry, Pharmacy or a related field with a strong interest in chemical synthesis and in biological systems.
- A high interest in interdisciplinary work with the willingness to evaluate the synthesised compounds in vitro is required.
- You should have good social skills for working with a team of people from different scientific fields.
- Research experience abroad would be of benefit and fluent English is required.

**We offer**:

- The position offers the unique opportunity to be part of a multidisciplinary team to shape the development of innovative cancer therapies.Working, teaching and research at ETH Zurich

**We value diversity**:

- In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

**Curious? So are we.**:

- Motivation letter
- Curriculum Vitae including most important scientific achievements
- References

**About ETH Zürich**:

- ETH Zurich is one of the world’s leading universities specialising in
- science and technology. We are renowned for our excellent education,
- cutting-edge fundamental research and direct transfer of new knowledge
- into society. Over 30,000 people from more than 120 countries find our
- university to be a place that promotes independent thinking and an
- environment that inspires excellence. Located in the heart of Europe,
- yet forging connections all over the world, we work together to
- develop solutions for the global challenges of today and tomorrow.

**Requirements**:
**Research Field**
- Chemistry**Years of Research Experience**

1 - 4

**Research Field**
- Biological sciences**Years of Research Experience**

1 - 4

**Research Field**
- Chemistry**Years of Research Experience**

1 - 4

**Research Field**
- Pharmacological sciences**Years of Research Experience**

1 - 4

**Additional Information**:
**Website for additional job details**Work Location(s)**:
**Number of offers available**
- 1**Company/Institute**

ETH Zurich

**Country**

Switzerland

**City**

Zurich

**Postal Code**

8006

**Street**

Rämistrasse 101

**Where to apply**:
**Website**Contact**:
**City**
- Zurich**Postal Code**
- 8006

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