Protein Scientist

Vor 5 Tagen

Basel, Schweiz Hengrui Europe Therapeutics AG Vollzeit

**Company**: HENGRUI EUROPE BIOSCIENCES

**Job Title**: Protein Scientist

**Department**: Protein Science

**Location**: Zürich, Switzerland

**About Hengrui**:
Hengrui is the biggest Chinese pharma company with 25’000 employees, headquartered in Shanghai. With strong research focus in oncology, diabetes and metabolic diseases, autoimmune diseases, HIV, we have just started transforming into a global player. In 2020, we established our entities in Europe and USA. We are building a new clinical R&D unit headquartered in Basel, Switzerland. We are also building pre-clinical labs in Zürich Switzerland with focus on antibody engineering, mRNA therapeutics and target discovery. We are bringing top European pharma talent to help us build a new exciting international team in the heart of Europe.

**About this job**:
Tasks

**Job responsibilities**:
**Essential Job Functions**:
Purification
- Develop routine FPLC purification methods required for isolating antibodies or other proteins from host cell components, to achieve high purity and yield.
- Utilize low-volume, high-throughput purification methods to support rapid antibody discovery-stage screening workflows.
- Introduce process optimizations where required, to ensure required purity and yield.

Biophysical analysis
- Lead the biophysical characterisation of antibodies and other proteins, including use of HPLC methods, Tm determination, aggregation profiling and stability studies.
- Develop mass spectrometry methods to deliver detailed characterization of antibodies and support developability assessments.

Protein function
- Contribute to the design, optimization and reformatting of antibody sequences.
- Design required target antigens suitable for use in discovery campaigns.
- Analyse antibody binding to targets, both as recombinant protein and also on cells.

Teamwork
- Utilize strong teamworking skills to support the group leader and mentor junior group members.
- Collaborate scientifically and strategically in a multi-disciplinary matrix environment, interacting frequently with local and global colleagues to achieve project success.
- Coordinate group project responsibilities and prioritize work accordingly, to meet agreed timelines and goals

**Requirements**:
**Job requirements**:
Experience / Education
- PhD in biochemistry, molecular biology, biophysics or similar.
- 3 years’ experience in antibody discovery, focused on purification and biophysical characterization.
- Strong expertise in analysing the biophysical properties of antibodies, including mass spectrometry
- Experience of antibody optimization and characterization of binding specificity and kinetics.

**Knowledge / Skills / Abilities**:

- Deep knowledge of the early R&D phases of antibody discovery.
- Strong scientific background in the biophysical characteristics of antibodies, with hands-on experience of biophysical methods, such as HPLC, DSF, DLS and mass spectrometry.
- Expertise in ‘Design of Experiment’ (DoE) approaches to determine optimal purification process conditions is an advantage.
- Experience developing high throughput or automated workflows for rapid processing and accurate analysis of therapeutics antibodies.
- Good understanding of techniques for assessing antibody binding, including ELISA, SPR/BLI and flow cytometry.
- Able to communicate scientific concepts across all levels of the organization and interacting with stakeholders.
- Experience supervising and mentoring junior colleagues.
- Flexible team player that can quickly adapt to changing situations.
- Highly collaborative spirit, able to work well within a multi-functional matrix environment.
- Experience leading communication with external collaborators and CROs.
- Knowledge of bioinformatics or advanced computational analysis is an advantage.
- Accurate reporting and presentation skills.
- Knowledge of German or Chinese is an advantage.
- Some infrequent international travel may be required, ≤ 5% travel.

**Benefits**:
I look forward to receiving your CV.

I look forward to receiving your CV.

  • Research Scientist

    vor 6 Monaten

    Basel, Schweiz Novartis Vollzeit

    394899BR **Research Scientist (Protein Sciences)**: Switzerland **About the role** **Location: Basel, Switzerland (Onsite)** **#LI-Onsite** We are seeking a passionate, curious, and collaborative protein scientist with demonstrated experience in expression optimization and characterization of challenging proteins or who is a fast learner and...

  • Research Scientist, Protein Mass Spectrometry

    Vor 4 Tagen

    Basel, Schweiz Novartis Vollzeit

    **Research Scientist, Protein Mass Spectrometry, Novartis, Basel, Switzerland** 6500! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.- This role...

  • Research Scientist Ii Mammalian Protein Expression

    vor 6 Monaten

    Basel, Schweiz Novartis Vollzeit

    394915BR **Research Scientist II Mammalian Protein Expression (6 month FTC)**: Switzerland **About the role** **Location: Basel, Switzerland (Onsite)** **#LI-Onsite** **TEMPORARY POSITION FOR 6 MONTHS** Biomedical Research (BR) is the global pharmaceutical research organization of Novartis. With approximately 5,400 scientists and physicians around the...

  • Research Scientist Protein Physicalchemical

    Vor 4 Tagen

    Basel, Schweiz Novartis Vollzeit

    **Research Scientist Protein Physicalchemical Characterization(80-100%*), Novartis, Basel, Switzerland** 6500! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs...

  • Analytical Scientist

    vor 2 Monaten

    Basel, Schweiz Eurofins Agro NL Vollzeit

    Analytical Scientist (Protein Analytics) (all genders)Full-timeEurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. Eurofins works with the biggest companies in the world to ensure...

  • Junior Scientist

    Vor 3 Tagen

    Basel, Schweiz Batterman Consulting Basel AG Vollzeit

    **Our Client** **Junior Scientist (m/w)****: **Your responsibilites** - In close collaboration with biology/chemistry group leaders and scientists design, develop, execute and analyze a variety of experiments, including but not limited to: - RNA/DNA isolation, RT-PCR, electrophoresis, RT-qPCR for analysis of gene expression and detection of splice...

  • Analytical Scientist

    vor 6 Monaten

    Basel, Schweiz Eurofins Switzerland PSS Vollzeit

    **Company Description** Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the...

  • Dna-encoded Library Screening Scientist

    vor 7 Monaten

    Basel, Schweiz GITR Vollzeit

    **EINFÜHRUNG**: As a preferred supplier for Roche Basel, we are looking for an individual as **DNA-Encoded Library Screening Scientist**: with contract for 9 months, with possible extension. The earliest start date is within 3 months. Remote/Home Office possible (but mostly lab based work on-site). **AUFGABENBESCHREIBUNG**: - Conduct DNA-encoded library...

  • Junior Scientist

    Vor 3 Tagen

    Basel, Schweiz Batterman Consulting Basel AG Vollzeit

    Our Client Tasks - In close collaboration with biology/chemistry group leaders and scientists design, develop, execute and analyze a variety of experiments, including but not limited to: - RNA/DNA isolation, RT-PCR, electrophoresis, RT-qPCR for analysis of gene expression and detection of splice variants; - Mammalian cell culture,...

  • Expert Science

    vor 4 Monaten

    Basel, Schweiz Datalynx AG Vollzeit

    For our client, a well-known pharmaceutical company in Basel, we are looking for an Expert Science & Technology - Lab Scientist (m/w/d). **Background** As Expert / Lab Scientist you will play a key role in the development of formulations and processes for parenteral dosage forms of Biologics (e.g. therapeutic proteins, conjugates and other new modalities)...

  • Research Scientist

    vor 7 Monaten

    Basel, Schweiz Novartis Vollzeit

    385246BR **Research Scientist - Biochemistry & Oncology (80-100%*)**: Switzerland **About the role** Your role will be to contribute to the identification and characterization of chemical entities that will become anticancer drugs of the future. We seek for an experienced and motivated Research Scientist associate who will contribute in pushing the...

  • Principal Scientist

    vor 7 Monaten

    Basel, Schweiz Novartis Vollzeit

    385241BR **Principal Scientist - Biochemistry & Oncology (80-100%*)**: Switzerland **About the role** Location: Basel, Switzerland Full time, onsite #onsite Your role will be to contribute to the identification and characterization of chemical entities that will become the anticancer drugs of the future. We seek an experienced and motivated researcher...

  • Dna-encoded Library Screening Scientist

    vor 7 Monaten

    Basel, Schweiz CTC Resourcing Solutions Vollzeit

    **The Life Science Career Network** Our client is a pioneer in Drug Discovery and Development and one of the frontrunners in Personalised Healthcare. As the world's largest R&D spender in the pharmaceutical and diagnostics domain, they work in a vast number of drug discovery & therapeutic areas and are highly recognized internationally. We are currently...

  • Principal Scientist, Machine Learning

    vor 1 Monat

    Basel, Schweiz F. Hoffmann-La Roche Gruppe Vollzeit

    Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche,...

  • Principal Scientist

    vor 5 Stunden

    Basel, Schweiz Novartis Vollzeit

    1 out of 10 people are suffering from immunological diseases. The Immunology Disease Area at the Novartis Institutes for Biomedical Research (NIBR) is investing in the discovery of novel and transformative therapies to improve the life of affected patients. As part of this effort, we are seeking an innovative and highly motivated Principal Scientist or...

  • (Senior) Scientist

    vor 3 Wochen

    Basel, Schweiz Matterhorn Biosciences AG Vollzeit

    Ridgeline Discovery is looking for a(Senior) Scientist / Principal Scientist, Computational Chemistry /CADD, Cheminformatics and AI/ML platforms as applied to Drug Discovery.Ridgeline Discovery, a Versant Ventures Discovery Engine, creates and operates Versant-financed innovative biotech companies in partnership with entrepreneurs, industry, and leading...

  • Senior Analytical Development Scientist

    vor 1 Tag

    Basel, Basel-Stadt, Schweiz Gi Group SA Vollzeit

    At Gi Group SA, we are looking for a skilled and experienced Senior Analytical Development Scientist to join our team. This is a 100% position based in Basel.About the JobWe are searching for someone with experience within the field of analytical development and related methods. The ideal candidate will have a strong theoretical and scientific knowledge as...

  • Mass Spectrometry Scientist

    vor 7 Monaten

    Basel, Schweiz Genedata Vollzeit

    Genedata transforms data into intelligence with innovative software solutions that incorporate extensive biopharma R&D domain knowledge. Multinational biopharmaceutical organizations and cutting-edge biotechs around the globe rely on Genedata to digitalize and automate data-rich and complex R&D processes. From early discovery all the way to the clinic,...

  • Scientist - Cellular and Soluble Biomarkers and

    vor 7 Monaten

    Basel, Schweiz CTC Resourcing Solutions Vollzeit

    **The Life Science Career Network** Our client is a pioneer in Drug Discovery and Development and one of the frontrunners in Personalised Healthcare. As the world's largest R&D spender in the pharmaceutical and diagnostics domain, they work in a vast number of drug discovery & therapeutic areas and are highly recognized internationally. We are currently...

  • Postdoctoral Fellow: Immunology and Nanomedicine

    vor 7 Monaten

    Basel, Schweiz Universität Basel Vollzeit

    The Department of Pharmaceutical Sciences of the University of Basel is an Academic Drug Discovery & Development Center, which comprehensively covers academic drug research throughout pre-clinical and clinical research phases. The Nanopharmaceutical and Regulatory Science Group (NRSG) within the Department is searching for a PhD-level scientist with training...