Research Assistant Position

vor 7 Monaten

Basel, Schweiz Universität Basel Vollzeit

The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 900 employees, the Department of Biomedicine is the largest department at the University. We are located in the heart of Basel across 6 different locations. Be part of our future

Prof. Beltra's group is studying the factors governing T-cell differentiation programs in settings of viral infections and cancers. Notably, we are particularly interested in identifying new pathways regulating the process of CD8 T cell exhaustion, an hypofunctional program acquired by CD8 T cells exposed to persistent inflammation and antigenic stimulation. Indeed, CD8 T cell exhaustion represents a central limitation to current anti-cancer immunotherapies and strategies aiming at reversing this process are still lacking. By exploring the intimate mechanisms regulating CD8 T cell exhaustion, our group aims to identify innovative opportunities to reverse this process and unleash the full potential of current cancer immunotherapies (e.g. PD-1-based therapy). To this end, we have developed relevant murine models for the study of CD8 T cell-exhaustion and are leveraging cutting-edge technologies (single cell omics, ATACseq) and innovative immunological and genetic perturbation tools (Retroviruses, CRISPR), to identify and characterize new pathways of interest for a better therapeutic manipulation of exhausted CD8 T cells. Collectively, our group aims to lay the foundation for advancing next-generation cancer immunotherapies.

**Your position**
- Lab management (administrative coordination: orderings, inventory monitoring).
- Equipment calibration and maintenance.
- Preparation of common lab reagents.
- Cloning of proteins of interests in expression plasmids.
- Ensuring good lab practices and respect of Biosafety measures.
- Providing technical support and mentoring trainees and students.
- Participate in the lab experiments including experiments with mouse.

**Your profile**
- M.Sc. (or equivalent) in biological sciences or related-fields.
- Previous experience in lab management.
- Strong expertise in molecular biology (plasmid work, cloning) - Required
- Proficient in basic lab techniques (cell culture, PCR, working in sterile conditions).
- Previous experience with flow cytometry and mouse work (handling, injections).
- Interests in immunology, cancer immunobiology and/or cancer immunotherapy.
- Excellent written and communication skills.
- Fluent in French or English - Required

**We offer you**

**Application**

Apply

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