Research Assistant Molecular and Cell Biology

vor 4 Wochen

Basel, Schweiz Institute of Molecular and Clinical Ophthalmology Basel Vollzeit

IOB is a research institute combining basic and clinical research. Its mission is to drive innovations in understanding vision and its diseases and develop new therapies for vision loss. It is a place where your expertise will be valued, your abilities challenged, and your knowledge expanded. We are seeking a dynamic and driven individual to join our team as **Research Assistant Molecular and Cell Biology (100%) **with strong molecular biology and in vitro cell culture skills to support translational projects aimed at developing new therapies for ocular diseases

**Position overview**:

- and mRNA-display methods.
- and mRNA-display methods.

**Responsibilities**:

- Develop and maintain in vitro disease models from primary cells or induced pluripotent stem cells (iPSCs)
- Design and cloning of constructs for mammalian expression
- Participate in the development of new protocols for manufacturing of therapeutic molecules
- Assist in binder discovery campaigns and characterization of novel protein binders together with Protein Engineering Platform

**Requirements**:

- Degree (apprenticeship, BSc/MSc) in Biology, Biochemistry or similar discipline
- Proficiency in English (German is optional)
- Practical experience with cell culture (primary and immortalized cells maintenance, stable generation of organoids and stable cell lines)
- Experience in histology techniques (e.g. vibratome, cryotome)
- Knowledge of molecular cloning techniques
- Experience with basic molecular biology techniques (e.g. SDS-PAGE, ELISA, western blots, ddPCR)

Additional skills (advantageous but not required):

- Reprogramming iPSCs
- Generation of DNA libraries
- Experience with microscopy (confocal, super-resolution)
- Protein-protein interaction analysis, e.g. by ELISA, surface plasmon resonance, biolayer interferometry
- In-vitro display methods, e.g. phage, yeast or ribosome display

This position is hands-on and demands both an independent working style and an ability to interact comfortably with team members. Openness to innovative non-traditional solutions is important.

We offer
- Competitive salary among the academic world.
- Five weeks of vacation for all employees, with increasing amount of vacation days by age.
- Paid Maternity-leave up to 16 weeks plus the opportunity to extend it through unpaid leave.
- Opportunities for professional growth and development, including training and education support.
- Family Friendly: we offer childcare subsidy, a family room.
- The chance to be part of a groundbreaking research institute making a real impact in the field of medical science.
- Additional discounts and benefits: e.g. cafeteria, access to the Uni Sport offerings at university Basel, and more.

**Application / Contact**

Contact
IOB - Institute of Molecular and Clinical Ophthalmology Basel
Rebecca Brütsch
Head of Human Resources

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