Phd Position in Diffusion Functional Mri Simulations

Vor 5 Tagen

Lausanne, Schweiz Centre hospitalier universitaire vaudois Vollzeit

**Contexte**:
The Lausanne University Hospital (CHUV) is one of five Swiss university hospitals. Through its collaboration with the Faculty of Biology and Medicine of the University of Lausanne and the EPFL, CHUV plays a leading role in the areas of medical care, medical research and training.

You will be part of the Microstructure Mapping Lab, a research group of engineers, physicists and neuroscientists within the Department of Radiology at the Lausanne University Hospital (CHUV) and the University of Lausanne (UNIL), led by Dr. Ileana Jelescu. The group has access to state-of-the-art clinical MRI scanners (CHUV), preclinical MRI scanners (EPFL) and ample GPU computing. You will actively collaborate with Dr. Marco Palombo (Cardiff University, UK) as well as with clinicians and biologists. The CHUV and UNIL are founding partners of the CIBM Center for Biomedical Imaging, along with the EPFL, UniGE and HUG, with over 50 affiliate members - including our group - in a variety of disciplines ranging from MRI to signal processing, EEG and PET.

**Mission**:
The functional integrity of white matter withholds tremendous diagnostic and prognostic value for neurodegenerative diseases, psychiatric diseases and stroke. Non invasive mapping of activity within white matter fibers is currently out of reach, including for functional MRI (fMRI) techniques whose contrast relies on the hemodynamic response to neural activity. Diffusion fMRI (dfMRI) relies instead on activity-dependent dynamic fluctuations in neuron and astrocyte microstructure. Our recent work supports the detectability of genuine dfMRI contrast in the human gray matter. We propose FIREPATH, a dfMRI-based method that can fill the gap of detecting activity also in the brain white matter and enable a first-of-its-kind comprehensive mapping of brain function across gray and white matter on clinical MRI scanners.

The project was approved as an ERC Starting Grant and is funded by the SEFRI (Swiss relay to Horizon Europe), following Swiss National Science Foundation salary guidelines. Funding is available for four years.

**Profil**:

- You have a M.Sc. in physics, electrical engineering, biomedical engineering, computer science or related field
- You are a motivated student with initiative, curiosity, rigor and a strong scientific background
- Proficiency in programming is mandatory
- Master-level experience with MRI is a plus
- Excellent written and oral communication skills in English
- You adhere to the principles of open research.

**Nous offrons**:
**To become an employee of the world-famous University Hospital Center from the Canton of Vaud is an assurance of**:

- First class social benefits and 20 days paternity leave
- Regular salary progression in line with responsibilities
- A 13th salary and 25 days holiday per year
- A right to a minimum of three days of training per year, with access to a varied offer within the CHUV's Training Centre and the State of Vaud's partner training centres
- Easy access to one of the 500 furnished accommodations offered in the surrounding areas
- Social, cultural and economic benefits offered to members of the H-Oxygène association
- Benefits offered as part of the mobility plan (discounts on public transport passes, promotion of "Mobility" vehicles and discounts on the purchase of electric bicycles)
- Hotel-quality company restaurants in each of the hospital buildings with preferential rates.

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