Scientist, Functional Cancer Genomic

vor 4 Wochen

Basel, Schweiz F. Hoffmann-La Roche AG Vollzeit

Scientist, Functional Cancer Genomic

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Location: Basel

Time Type: Full time

Posted on: Posted 2 Days Ago

Job Requisition ID: 202502-105035

Roche fosters diversity, equity, and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicine. Together, we create a culture defined by curiosity, responsibility, and humility, where our dedicated people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

This position is located within our Discovery Research Units within the Oncology Discovery organization dedicated to the discovery and development of novel cancer therapeutics. We collaborate closely with functions in Therapeutic Modalities, Pharmaceutical Science as well as within the oncology therapeutic area to translate hypotheses into innovative therapeutics.

The Opportunity

  • Design and lead innovative research projects focused on target discovery and validation in cancer biology.

  • Apply cutting-edge functional genomic approaches, including CRISPR-based screening, to identify and characterize novel therapeutic targets.

  • Develop and optimize advanced 3D organoid models to investigate tumor biology and therapeutic responses.

  • Analyze large-scale genomic, proteomic, and transcriptomic datasets to uncover key disease mechanisms and potential therapeutic vulnerabilities.

  • Collaborate closely with multidisciplinary teams, including computational biologists, translational scientists, and clinical researchers, to drive data-driven discoveries.

  • Present research findings at internal meetings, scientific conferences, and contribute to high-impact peer-reviewed publications.

  • Stay at the forefront of emerging technologies and advancements in cancer biology to integrate the latest innovations into research programs.

Who you are

You have a Ph.D. in Cancer Biology, Molecular Biology, Genetics, or a related field and bring a strong background in at least one key disease area, such as colorectal cancer, lung cancer, or breast cancer. Further, you have proven expertise in functional genomics, particularly CRISPR/Cas9-based screening techniques and hands-on experience with 3D organoid culture systems and their application in disease modelling. Ideally, you also bring a couple of years of postdoctoral or industry experience in oncology drug discovery or translational cancer research/biology. Familiarity with in vivo cancer models and their translational applications would also be of advantage. Further you have:

  • Strong proficiency in analysing genomic, transcriptomic data using bioinformatics tools.

  • Advanced Flow Cytometry & Cell Sorting skill: Proficiency in multi-color flow cytometry, including spectral flow and FACS-based cell isolation.

  • Experience in cell-based assays for target validation (e.g., live-cell imaging, proliferation, apoptosis, migration, and invasion assays).

  • Demonstrated track record of impactful scientific publications in peer-reviewed journals.

  • Ability to work both independently and collaboratively in a dynamic and fast-paced research environment.

  • Excellent problem-solving, communication, and organizational skills.

  • Experience managing projects, setting priorities, and aligning research goals with translational applications.

  • Strong problem-solving mindset with a willingness to integrate emerging technologies into research workflows.

Unwavering focus, collaborative teamwork, and exceptional delivery are key behaviours that drive our mission of doing now what patients need next. Together, we can be transformative.

If you are passionate about contributing to a committed team and have the dedication to partnership and innovation, Roche is the place for you Every role at Roche plays a part in making a difference in patients’ lives. Apply now and join us in making an impact

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity, and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche's largest sites.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave, and 10 weeks of gender-independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

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