Postdoctoral Scientist in Tissue Engineering of Orthopaedic Implants
Vor 3 Tagen
ETH Zürich is well known for its excellent education, ground-breaking fundamental research and for implementing its results directly into practice.
Human joints must withstand a lifetime of physical loading. The interface between cartilage-bone interface, or osteochondral (OC) unit, is a site of frequent injury. In addition, diseases such as osteoarthritis (OA) cause pathological changes to the OC unit, involving cartilage destruction, sclerotic bone, and pain, which can ultimately necessitate total joint arthroplasty (TJA). The field of tissue engineering is searching for new methods to create biomimetic tissue models which better replicate the organization of native osteochondral junction. We believe these advances can one day be used to resurface osteoarthritic joints. Our goal is to improve treatment of joint disease by matching natural biomechanics, promoting tissue regeneration, and avoiding synthetic materials prone to wear and failure. The methodology we will develop could one day provide robust, biocompatible solutions for OC regeneration of the aging population.
Project backgroundYou will join a multi-PI consortium consisting of biomedical engineers and clinicians. We aim to use natural materials to bioengineer patient-specific osteochondral grafts that mimic the architecture, zonal organization and functional properties of native OC tissue as closely as possible. The osteochondral unit is comprised of transitions from hyaline articular cartilage, calcified cartilage zone, subchondral bone plate and subchondral cancellous bone. Using 3D computer models based on native subchondral bone architecture, a high-resolution model of the subchondral microarchitecture will be printed from a bioceramic known for its outstanding toughness, strength and osseointegrative properties. Cellular layers of hyaline and calcified cartilage will be bonded to the bioceramic base and matured in a bioreactor until matching the native tissue. The efficacy of these personalized grafts to regenerate OC lesions will be tested in an articular cartilage/subchondral bone defect model in sheep. We hypothesize that these OC implants will be able to 1) restore the load-carrying capacity of the joint, 2) provide a mechanically stable support bed for the hyaline cartilage layer and 3) promote physiologic cartilage/bone crosstalk needed for long term joint homeostasis.
- Development and validation of a functional in vitro osteochondral tissue model based on 3D printed ceramic and engineered cartilage
- Study of crosstalk and transport across the tissue interface
- Upscale of technology and show proof-of-concept resurfacing of arthritic joints
- Development of surgical implantation strategies
- Project coordination between the consortium partners and training of clinical partners
- Project reporting
You have a PhD in biomedical engineering, mechanical engineering, material science or related fields. Previous experience in cartilage/bone tissue engineering, biomaterials, biomechanics, and surgical instrumentation is advantageous. A flair for excellent written and oral communication as well as effective managerial skills are essential.
We offerThe open position is in the Tissue Engineering and Biofabrication Laboratory (Prof. Marcy Zenobi-Wong) within the Department of Health Sciences & Technology (D-HEST) at ETH Zürich in Zurich, Switzerland. We offer you a stimulating, collaborative, cross-disciplinary environment in a world-class research institution. ETH Zürich is an outstanding employer with excellent compensation and benefits, with ample opportunities for career development and mentoring. We encourage experimentation and creativity by actively promoting the learning of new technologies and approaches on the job.
In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.
Curious? So are we.Curious? We look forward to receiving your application
Your online application includes the following documents:
- CV and publication list
- Description of research interests
- Name and contact information of 3-4 references
The position is available from immediately and is funded for at least 2 years.
Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
Further information about our Institute and Laboratory can be found on our website. Questions regarding the position should be directed to Prof. Marcy Zenobi-Wong, email: marcy.zenobi@hest.ethz.ch (no applications).
Job detailsTitle
Postdoctoral Scientist in Tissue Engineering of Orthopaedic Implants
#J-18808-Ljbffr-
Zürich, Schweiz Eidgenössische Technische Hochschule Zürich VollzeitPostdoctoral Scientist in Tissue Engineering of Orthopaedic ImplantsHuman joints must withstand a lifetime of physical loading. The interface between the cartilage-bone interface, or osteochondral (OC) unit, is a site of frequent injury. In addition, diseases such as osteoarthritis (OA) cause pathological changes to the OC unit, involving cartilage...
-
Zürich, Schweiz ETH get hired VollzeitPostdoctoral Scientist in Tissue Engineering of Orthopaedic Implants100 %BrancheRegionJob DescriptionHuman joints must withstand a lifetime of physical loading. The interface between cartilage-bone interface, or osteochondral (OC) unit, is a site of frequent injury. Diseases such as osteoarthritis (OA) cause pathological changes to the OC unit, involving...
-
Zürich, Schweiz Eidgenössische Technische Hochschule Zürich VollzeitPostdoctoral Position at the Chair of Circular Engineering for ArchitectureThe Chair of Circular Engineering for Architecture (CEA) is seeking a highly motivated and qualified postdoctoral candidate in the field of digital technologies for circular economy in the construction sector. The successful candidate will join a dynamic research team working on...
-
Zürich, Schweiz TN Switzerland VollzeitPostdoctoral Position at the Chair of Circular Engineering for Architecture, ZürichClient:D-BAUG - IBI - CEALocation:ZürichJob Reference:446c49a168c7Job Views:9Posted:21.01.2025Expiry Date:07.03.2025Job Description:Development of theoretical concepts for tools leveraging digital technologies for circular construction, facilitating circular processes along...
-
Postdoctoral Researcher
vor 2 Wochen
Zürich, Schweiz Unist VollzeitOrganisation/Company: ETH ZürichResearch Field: Engineering » Control engineering, Engineering » Mechanical engineering, Engineering » Systems engineeringResearcher Profile: Recognised Researcher (R2)Country: SwitzerlandApplication Deadline: 3 Apr 2025 - 21:59 (UTC)Type of Contract: TemporaryJob Status: Part-timeHours Per Week: 41Is the job funded...
-
Zürich, Schweiz University of Groningen VollzeitMonday, 16 December 2024 08:41Postdoctoral Researcher in Sustainability Economics, ETH Zurich, SwitzerlandPostdoctoral Researcher in Sustainability EconomicsThe Sustainability Economics Group, led by Prof. Dr. Moritz Drupp, seeks to inform and support the transition to sustainable futures. We investigate how society can manage natural and human-made...
-
Postdoctoral Researcher
Vor 6 Tagen
Zürich, Schweiz EURAXESS Czech Republic VollzeitOrganisation/Company: ETH ZürichResearch Field: Engineering » Control engineering, Engineering » Mechanical engineering, Engineering » Systems engineeringResearcher Profile: Recognised Researcher (R2)Country: SwitzerlandApplication Deadline: 3 Apr 2025 - 21:59 (UTC)Type of Contract: TemporaryJob Status: Part-timeHours Per Week: 41Is the job funded...
-
Postdoctoral Researcher
Vor 6 Tagen
Zürich, Schweiz Euraxess VollzeitOrganisation/Company: ETH ZürichResearch Field: Engineering » Control engineering, Engineering » Mechanical engineering, Engineering » Systems engineeringResearcher Profile: Recognised Researcher (R2)Country: SwitzerlandApplication Deadline: 3 Apr 2025 - 21:59 (UTC)Type of Contract: TemporaryJob Status: Full-timeHours Per Week: 41Is the job funded...
-
Tissue Culture Specialist
Vor 6 Tagen
Zürich, Schweiz Lumino VollzeitTissue Culture Specialist - Driving Innovation in Crop BreedingLocation: SwitzerlandIndustry: Hemp – Plant Breeding, Biotechnology, Agricultural InnovationCompany OverviewOur client is a pioneering force in agricultural innovation, focused on breeding high-yield, pest-resistant, and climate-adaptable cannabis and hemp varieties. Leveraging cutting-edge...
-
Postdoctoral position
Vor 4 Tagen
Zürich, Schweiz Institute of Environmental Engineering VollzeitJob description The candidate will be the project coordinator for a running project about circularity in the building sector with a team of 15 researchers. The candidate will co-supervise two doctoral students of the Ecological Systems Design Group and collaborate with them on the development of frameworks for assessing circular economy strategies....
-
Zürich, Schweiz Department of Management, Technology, and Economics VollzeitJob description We are seeking a postdoctoral researcher with a background in agricultural economics. The position consists of five main tasks: i) Development of a research profile focusing on farmers' decision making in the context of sustainable agricultural practices, e.g. by analysing survey, experimental, and census data. The focus will be on...
-
Postdoctoral Researcher in Responsible Automation
vor 2 Wochen
Zürich, Schweiz Karlstad University VollzeitPostdoctoral Researcher in Responsible Automation ETH Zürich is well known for its excellent education, ground-breaking fundamental research and for implementing its results directly into practice. The Frazzoli group at the Institute for Dynamic Systems and Control, Department of Mechanical and Process Engineering (D-MAVT) is looking for a postdoctoral...
-
Zürich, Schweiz TN Switzerland VollzeitSocial network you want to login/join with:Postdoctoral Position at the Chair of Structural Design, ZürichClient:Location:Job Category:OtherJob Reference:8d3aa6997137Job Views:9Posted:21.01.2025Expiry Date:07.03.2025Job Description:The position involves writing grant applications both in Switzerland and the EU, setting up a research environment for the...
-
Postdoctoral Researcher
vor 2 Wochen
Zürich, Schweiz ETH get hired Vollzeit100 %0 weekly hoursEducation / CultureFunctional AreaAcademic Research / Teaching0 /Entry dateJanuary 1, 1RegionPostdoctoral ResearcherThe Frazzoli group at the Institute for Dynamic Systems and Control, Department of Mechanical and Process Engineering (D-MAVT) is looking for a postdoctoral researcher to work in the context of NCCR Automation on the broad...
-
Zürich, Schweiz Department of Mechanical and Process Engineering VollzeitJob description This experimental research work will be performed on a lab-scale, high-pressure test facility into which a hydrogen sequential combustor can be inserted. Laser-based optical diagnostics and plasma emission spectroscopy will be used to experimentally characterize the effects of repetitively pulsed nanosecond discharges on the...
-
Zürich, Schweiz Eidgenössische Technische Hochschule Zürich VollzeitPostdoctoral Researcher in Responsible AutomationThe Frazzoli group at the Institute for Dynamic Systems and Control, Department of Mechanical and Process Engineering (D-MAVT) is looking for a postdoctoral researcher to work in the context of NCCR Automation on the broad theme of Responsible Automation (how to align control and design objectives with...
-
Zürich, Schweiz Biomechanics Summer Course VollzeitHome » Job Posting » PhD on Computational Assessment of Spinal Instability in ScoliosisPhD on Computational Assessment of Spinal Instability in ScoliosisAre you eager to understand how instability in the growing spine can lead to excessive tissue strains and whether this could result in scoliosis?Adolescent Idiopathic Scoliosis (AIS) is a 3D deformity of...
-
Postdoctoral Researcher
Vor 6 Tagen
Zürich, Schweiz NZZone VollzeitThe Frazzoli group at the Institute for Dynamic Systems and Control, Department of Mechanical and Process Engineering (D-MAVT) is looking for a postdoctoral researcher to work in the context of NCCR Automation on the broad theme of Responsible Automation (how to align control and design objectives with societal interest).The position is available...
-
Sales Representative Medical Devices Spine
Vor 3 Tagen
Zürich, Schweiz TN Switzerland VollzeitClient: LHHLocation: SwitzerlandJob Category: Job search engineJob Reference: c1259322bca5Job Views: 10Posted: 21.01.2025Expiry Date: 07.03.2025Job Description:LHH Recruitment Solutions is a specialized talent recruitment agency. We provide tailored services to help companies find the best candidates for their staffing needs.With deep industry expertise and...
-
Zürich, Schweiz Karlstad University VollzeitPostdoctoral Researcher Integrated Energy System ModellingETH Zürich is well known for its excellent education, ground-breaking fundamental research and for implementing its results directly into practice.About the Energy Science Center (ESC)The Energy Science Center (ESC) at ETH Zurich is an interdepartmental competence centre that facilitates energy...
